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ChemicalBook >> CAS DataBase List >>4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE

4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE

CAS No.
221243-82-9
Chemical Name:
4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE
Synonyms
CS-2001;1-NA-PP1;1-Naphthyl PP1;1-NAPHTHYL PP1(1-NA-PP 1);1-Naphthyl PP1, 10 mM in DMSO;1-Naphthyl PP1, PKD inhibitor;4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE;1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine;1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine,1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-
CBNumber:
CB4413972
Molecular Formula:
C19H19N5
Molecular Weight:
317.39
MDL Number:
MFCD03425471
MOL File:
221243-82-9.mol
Last updated:2025-01-27 09:38:02

4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE Properties

Melting point 219-222°C
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
UNSPSC Code 12352202

4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10954 1-NA-PP1 ≥98% 221243-82-9 1mg $23 2024-03-01 Buy
Cayman Chemical 10954 1-NA-PP1 ≥98% 221243-82-9 5mg $104 2024-03-01 Buy
Cayman Chemical 10954 1-NA-PP1 ≥98% 221243-82-9 10mg $180 2024-03-01 Buy
Cayman Chemical 10954 1-NA-PP1 ≥98% 221243-82-9 50mg $717 2024-03-01 Buy
Tocris 3063 1-NaphthylPP1 ≥99%(HPLC) 221243-82-9 50 $1184 2021-12-16 Buy
Product number Packaging Price Buy
10954 1mg $23 Buy
10954 5mg $104 Buy
10954 10mg $180 Buy
10954 50mg $717 Buy
3063 50 $1184 Buy

4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE Chemical Properties,Uses,Production

Chemical Properties

White Cyrstalline Solid

Uses

A highly potent (IC50=1.5nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase

Definition

ChEBI: 1-NA-PP1 is a pyrazolopyrimidine. It has a role as a tyrosine kinase inhibitor.

Biological Activity

Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC 50 values are 1.0, 0.6, 0.6, 18 and 22 μ M for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC 50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).

Synthesis

Add 3-iodo-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine into a 250mL three-necked flask, dissolve in 300ml 10% Na2CO3, add 150ml dioxane, After cooling to 0 °C, Fmoc boronate was dissolved in 225 ml of acetone and added dropwise to the system. Stir at room temperature for 3h, pour into 1000ml of water, extract twice with ether, cool and adjust pH to about 2 with concentrated hydrochloric acid, extract with ethyl acetate (3×100ml), dry over MgSO4, evaporate the solvent, and rotate under reduced pressure. The crude product is subjected to silica gel column chromatography (V methanol: V dichloromethane=1:35) to give 4-amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-D] pyrimidine as a white crystal-like solid .

storage

+4°C

4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE Suppliers

Global( 108)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29808 58
Finetech Industry Limited 		+86-27-8746-5837 +8619945049750 info@finetechnology-ind.com China 9642 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9984 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58

View Lastest Price from 4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE pictures 2020-01-14 4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE
221243-82-9
 US $9.80 / KG 1g ≥99% 100kg Career Henan Chemical Co

221243-82-9(4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE)Related Search:

4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE 1-NA-PP1 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-Naphthyl PP1 1-NAPHTHYL PP1(1-NA-PP 1) CS-2001 1H-Pyrazolo[3,4-d]pyrimidin-4-amine,1-(1,1-dimethylethyl)-3-(1-naphthalenyl)- 1-Naphthyl PP1, PKD inhibitor 1-Naphthyl PP1, 10 mM in DMSO 221243-82-9 C19H19N5 Other APIs Bases & Related Reagents Intermediates & Fine Chemicals Nucleotides Pharmaceuticals Tyrosine Kinase Inhibitors Intracellular Signaling