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ChemicalBook >> CAS DataBase List >>(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride

(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride

CAS No.
300576-59-4
Chemical Name:
(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride
Synonyms
(+/-)-PD 128;(+)PD 128907;(+)-PD 128970 HCl;(+)-PD 128907 HCl;(+)-PD 128907 HCl, >=98%;(+)-PD 128907 HYDROCHLORIDE;(+/-)-PD 128,907 HYDROCHLORIDE;(+)-PD 128907 hydrochloride, 10 mM in DMSO;(4aR,10bR)-rel-4-Propyl-2,3,4,4a,5,10b-hexahydrochroMeno[4,3-b][1,4]oxazin-9-ol;(4aR,10bR)-4-propyl-2,3,4,4a,5,10b-hexahydrochroMeno[4,3-b][1,4]oxazin-9-ol hydrochloride
CBNumber:
CB22129471
Molecular Formula:
C14H19NO3HCl
Molecular Weight:
285.77
MDL Number:
MFCD00210210
MOL File:
300576-59-4.mol
MSDS File:
SDS
Last updated:2025-04-28 21:36:36

(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride Properties

storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility ethanol: >10mg/mL
form solid
color off-white
Water Solubility Soluble to 10 mM in water
InChIKey DCFXOTRONMKUJB-QMDUSEKHSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
Safety Statements  24/25
WGK Germany  3

(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P183 (+)-PD 128,907 hydrochloride >97%, solid 300576-59-4 5mg $601 2023-01-07 Buy
Sigma-Aldrich P183 (+)-PD 128,907 hydrochloride >97%, solid 300576-59-4 25mg $2100 2022-05-15 Buy
Cayman Chemical 21235 (+)-PD 128907 (hydrochloride) ≥98% 300576-59-4 1mg $32 2024-03-01 Buy
Cayman Chemical 21235 (+)-PD 128907 (hydrochloride) ≥98% 300576-59-4 5mg $139 2024-03-01 Buy
Cayman Chemical 21235 (+)-PD 128907 (hydrochloride) ≥98% 300576-59-4 10mg $214 2024-03-01 Buy
Product number Packaging Price Buy
P183 5mg $601 Buy
P183 25mg $2100 Buy
21235 1mg $32 Buy
21235 5mg $139 Buy
21235 10mg $214 Buy

(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride Chemical Properties,Uses,Production

Uses

(+)-PD 128907 Hydrochloride is a potent D3 receptor agonist.

Biological Activity

Potent D 3 dopamine receptor agonist (K i = 2.3 nM). Displays 18-200-fold selectivity over other dopamine receptor subtypes.

in vivo

(+)-PD 128907 significantly decreases dialysate DA levels in D3 knock out mice. The IC25 values are 61 nM and 1327 nM, respectively, for wild type and D3knock out mice. The ratio of the IC25 values shows that (+)-PD 128907 is 22 times more potent in decreasing dialysate DA levels in wild type as compared to mice lacking the D3 receptor. The D3 agonist evokes a dose related decrease in dialysate DA in wild type mice. Post-hoc analysis shows that all doses tested (0.03, 0.1 and 0.3 mg/kg) significantly inhibit dialysate DA. The IC25 values are 0.05 and 0.44 mg/kg for wild type and knock out mice, respectively, indicating that systemically administered (+)-PD 128907 is 9 times more potent in decreasing dialysate DA in the ventral striatum of wild type as compared to D3 knock out mice. Doses of 1 mg/kg or higher of (+)-PD 128907 markedly inhibits dialysate DA in both wild type and D3 knock out mice[3].

IC 50

D3 Receptor; D2 Receptor

storage

Store at +4°C

(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride Suppliers

Global( 73)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32265 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38659 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Watson Biotechnology Co.,Ltd 		+86-18186686046 +86-18186686046 sales01@watsonbiotech.cn China 5849 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
821-50328103-801 18930552037 3bsc@sina.com China 15839 69
Chembest Research Laboratories Limited +86-21-20908456 sales@BioChemBest.com China 6005 61

View Lastest Price from (+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(+)-PD 128907 hydrochloride pictures 2025-04-27 (+)-PD 128907 hydrochloride
300576-59-4
 US $53.00-167.00 / mg 98.71% 10g TargetMol Chemicals Inc.

(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride Spectrum

(+/-)-PD 128,907 HYDROCHLORIDE (+)-PD 128907 HYDROCHLORIDE (+)-(4ar,10br)-3,4,4a,10b-tetrahydro-4-propyl-2h,5h-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride (S)-(+)-(4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride (4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-olhydrochloride (4aR,10bR)-4-propyl-2,3,4,4a,5,10b-hexahydrochroMeno[4,3-b][1,4]oxazin-9-ol hydrochloride (4aR,10bR)-rel-4-Propyl-2,3,4,4a,5,10b-hexahydrochroMeno[4,3-b][1,4]oxazin-9-ol (+/-)-PD 128 (+)-PD 128907 HCl, >=98% (+)-PD 128970 HCl (4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol, hydrochloride (4aR,10aR)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-dioxa-1-azaphenanthren-6-ol hydrochloride (4aR,10bR)-4-Propyl-3,4,4a,10b-tetrahydro-2H,5H-chromeno[4,3-b][1,4]oxazin-9-ol hydrochloride (+)-PD 128907,Dopamine Receptor,inhibit,(+) PD 128907 hydrochloride,Inhibitor,(+)PD 128907 hydrochloride (+)PD 128907 (+)-PD 128907 HCl (+)-PD 128907 hydrochloride, 10 mM in DMSO 300576-59-4 Dopamine receptor