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ChemicalBook >> CAS DataBase List >>1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE

1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE

CAS No.
116457-99-9
Chemical Name:
1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE
Synonyms
THIOETHERAMIDE PC;WLWWVTPUDQTUJU-KDXMTYKHSA-N;Thioetheramide phosphorylcholine;1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE;1-PALMITYLTHIO-2-PALMITOYLAMINO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE;1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE;1,2-DIDEOXY-1-(S-HEXADECYL)THIO-2-(N-HEXADECANOYL)AMINO-SN-GLYCERYL-3-PHOSPHORYLCHOLINE;3,5-Dioxa-9-thia-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-7-[(1-oxohexadecyl)amino]-, inner salt, 4-oxide, (7S)-
CBNumber:
CB1453968
Molecular Formula:
C45H93N2O4PS
Molecular Weight:
789.27
MDL Number:
MFCD00211202
MOL File:
116457-99-9.mol
Last updated:2023-05-21 10:59:17

1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE Properties

storage temp. Store at -20°C
solubility Soluble in DMSO;Soluble in dimethyl formamide
form White solid.

1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 62750 Thioetheramide-PC ≥95% 116457-99-9 5mg $70 2024-03-01 Buy
Cayman Chemical 62750 Thioetheramide-PC ≥95% 116457-99-9 10mg $131 2024-03-01 Buy
Cayman Chemical 62750 Thioetheramide-PC ≥95% 116457-99-9 25mg $308 2024-03-01 Buy
ApexBio Technology C4894 Thioetheramide-PC 116457-99-9 25mg(solution) $533 2021-12-16 Buy
ApexBio Technology C4894 Thioetheramide-PC 116457-99-9 5mg(solution) $138 2021-12-16 Buy
Product number Packaging Price Buy
62750 5mg $70 Buy
62750 10mg $131 Buy
62750 25mg $308 Buy
C4894 25mg(solution) $533 Buy
C4894 5mg(solution) $138 Buy

1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE Chemical Properties,Uses,Production

Description

Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). The IC50 value for thioetheramide-PC is 2 μM at a substrate concentration of 0.5 mM. In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.

References

[1] yu l, deems r a, hajdu j, et al. the interaction of phospholipase a2 with phospholipid analogues and inhibitors[j]. journal of biological chemistry, 1990, 265(5): 2657-2664.
[2] balsinde j, balboa m a, insel p a, et al. regulation and inhibition of phospholipase a2[j]. annual review of pharmacology and toxicology, 1999, 39(1): 175-189.
[3] mallat z, lambeau g, tedgui a. lipoprotein-associated and secreted phospholipases a2 in cardiovascular disease[j]. circulation, 2010, 122(21): 2183-2200.

1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
BOC Sciences 16314854226 info@bocsci.com United States 9923 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9805 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58
Shanghai Universal Biotech Co.,Ltd 13774214275 zhouzz@univ-bio.com China 24998 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 400-6206333 18021050169 market@aladdin-e.com China 48461 58
SHANGHAI ZZBIO CO., LTD. 15102117276 19921389125 tech@zzbioco.com China 12065 58
ApexBio Technology -- sales@apexbt.com United States 6251 58
1,2-DIDEOXY-1-(S-HEXADECYL)THIO-2-(N-HEXADECANOYL)AMINO-SN-GLYCERYL-3-PHOSPHORYLCHOLINE 1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHOCHOLINE 1-PALMITYLTHIO-2-PALMITOYLAMIDO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE 1-PALMITYLTHIO-2-PALMITOYLAMINO-1,2-DIDEOXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE THIOETHERAMIDE PC Thioetheramide phosphorylcholine WLWWVTPUDQTUJU-KDXMTYKHSA-N 3,5-Dioxa-9-thia-4-phosphapentacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-7-[(1-oxohexadecyl)amino]-, inner salt, 4-oxide, (7S)- 116457-99-9 C40H83N2O5PS