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ChemicalBook >> CAS DataBase List >>GSK2795039

GSK2795039

CAS No.
1415925-18-6
Chemical Name:
GSK2795039
Synonyms
GSK2795039;GSK-2795039 (GSK 2795039;GSK2795039, 10 mM in DMSO;Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039;N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide;1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-
CBNumber:
CB13152080
Molecular Formula:
C23H26N6O2S
Molecular Weight:
450.56
MDL Number:
MFCD30489720
MOL File:
1415925-18-6.mol
Last updated:2025-01-27 09:38:02

GSK2795039 Properties

Boiling point 691.5±65.0 °C(Predicted)
Density 1.39±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMF:30.0(Max Conc. mg/mL);66.58(Max Conc. mM)
DMSO:66.27(Max Conc. mg/mL);147.07(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.44(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);44.39(Max Conc. mM)
form A solid
pka 6.99±0.30(Predicted)
color White to yellow
InChIKey FMWVTCZKCXPKFW-UHFFFAOYSA-N
SMILES N1(C)C=CC(S(NC2C=CN=C3N(C(C)C)C=C(C4=CC5=C(C=C4)CCN5C)C3=2)(=O)=O)=N1
UNSPSC Code 12352200
NACRES NA.77

GSK2795039 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2770 GSK2795039 ≥98% (HPLC) 1415925-18-6 1MG $94.2 2024-03-01 Buy
Sigma-Aldrich SML2770 GSK2795039 ≥98% (HPLC) 1415925-18-6 5MG $381 2024-03-01 Buy
Tocris 6848 GSK2795039 ≥98%(HPLC) 1415925-18-6 25 $505 2021-12-16 Buy
ChemScene CS-5988 GSK2795039 98.14% 1415925-18-6 10mg $600 2021-12-16 Buy
ChemScene CS-5988 GSK2795039 98.14% 1415925-18-6 50mg $1800 2021-12-16 Buy
Product number Packaging Price Buy
SML2770 1MG $94.2 Buy
SML2770 5MG $381 Buy
6848 25 $505 Buy
CS-5988 10mg $600 Buy
CS-5988 50mg $1800 Buy

GSK2795039 Chemical Properties,Uses,Production

Biological Activity

GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. It inhibits reactive oxygen species (ROS) production, NADPH depletion and reduces apoptosis.

in vitro

GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells.

Apoptosis Analysis p>

< td class="col1"> Concentration: < td class="col2"> 24 hours td>
Cell Line: PC12 cells
25 μM
Incubation Time:
Result: Reduced apoptosis among PC12 cells.

target

TargetValue
ROS
()
NADPH
()
NOX2 (HRP/Amplex Red)
(Cell-based assay)		 6.57( pIC50)

storage

Store at -20°C

GSK2795039 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK2795039 Suppliers

Global( 56)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32965 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 7316 58
Nanjing Chemlin Chemical Co., Ltd 025-83697070 info@chemlin.com.cn China 19185 64
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58

View Lastest Price from GSK2795039 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GSK2795039 pictures 2024-11-19 GSK2795039
1415925-18-6
 US $67.00-255.00 / mg 98.68% 10g TargetMol Chemicals Inc.
  • GSK2795039 pictures
  • GSK2795039
    1415925-18-6
  • US $67.00-255.00 / mg
  • 98.68%
  • TargetMol Chemicals Inc.
GSK2795039 N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide GSK-2795039 (GSK 2795039 1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl- Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039 GSK2795039, 10 mM in DMSO 1415925-18-6