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Dehydroemetin

dehydroemetine Struktur
4914-30-1
CAS-Nr.
4914-30-1
Bezeichnung:
Dehydroemetin
Englisch Name:
dehydroemetine
Synonyma:
BT 436;Mebadin;Dametin;Ro 1-9334/19;dehydroemetine;2,3-DEHYDROEMETINE;dehydroemetine USP/EP/BP;Dehydroemetine hydrochloride;4H-Benzo[a]quinolizine, 3-ethyl-1,6,7,11b-tetrahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-, (11bS)-;(11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1H-pyrido[2,1-a]isoquinoline
CBNumber:
CB9942510
Summenformel:
C29H38N2O4
Molgewicht:
478.62
MOL-Datei:
4914-30-1.mol

Dehydroemetin Eigenschaften

Schmelzpunkt:
94-96°
alpha 
D -183°
Siedepunkt:
604.7±55.0 °C(Predicted)
Dichte
1.19±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
pka
8.86±0.40(Predicted)
Aggregatzustand
Solid
Farbe
Off-white to light yellow

Sicherheit

Dehydroemetin Chemische Eigenschaften,Einsatz,Produktion Methoden

Pharmazeutische Anwendungen

The synthetic racemic derivative of the plant alkaloid emetine. Formulated as the hydrochloride for intramuscular administration. Like the parent compound, emetine, it inhibits E. histolytica at concentrations of 1–10 mg/L in vitro, but it is more active than the parent in animal models. Drugresistance in E. histolytica is rare.
No human pharmacokinetic data are available. A halflife of 2 days, compared with 5 days for emetine, has been reported. There is selective tissue binding and accumulation in the liver, lung, spleen and kidney.
It is considerably less toxic than emetine, possibly because it is more rapidly eliminated. Nevertheless, nausea, vomiting, diarrhea and abdominal cramps frequently occur. Neuromuscular effects have also been reported. More serious cardiotoxic effects can lead to electrocardiogram (EGG) changes, tachycardia and a drop in blood pressure.
It was formerly used as a second-line treatment in severe intestinal or hepatic amebiasis, but is no longer recommended for use.

Dehydroemetin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dehydroemetin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 13)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22787 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501
product@acmec-e.com China 33338 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580
cooperation@kean-chem.com China 40066 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720
psaitong@jm-bio.com China 12306 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223;
psaitong@jm-bio.com China 29774 58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd 17691182729 18161915376
1046@dideu.com China 10001 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 24644 58

4914-30-1(Dehydroemetin)Verwandte Suche:


  • dehydroemetine
  • Dehydroemetine hydrochloride
  • BT 436
  • Dametin
  • Mebadin
  • Ro 1-9334/19
  • (11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1H-pyrido[2,1-a]isoquinoline
  • 2,3-DEHYDROEMETINE
  • 4H-Benzo[a]quinolizine, 3-ethyl-1,6,7,11b-tetrahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-, (11bS)-
  • dehydroemetine USP/EP/BP
  • 4914-30-1
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