JTE 907
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- CAS-Nr.
- 282089-49-0
- Englisch Name:
- JTE 907
- Synonyma:
- JTE 907;JTE907
(JTE-907;JTE-907, 10 mM in DMSO;N-(benzo[d][1,3]dioxol-5-ylMethyl)-7-Methoxy-2-oxo-8-(pentyl;N-(1,3-BENZODIOXOL-5-YLMETHYL)-1,2-DIHYDRO-7-METHOXY-2-OXO-8-(PENTYLOXY)-3-QUINOLINECARBOXAMIDE;3-QuinolinecarboxaMide,N-(1,3-benzodioxol-5-ylMethyl)-1,2-dihydro-7-Methoxy-2-oxo-8-(pentyloxy)-;N-(benzo[d][1,3]dioxol-5-ylmethyl)-7-methoxy-2-oxo-8-(pentyloxy)-1,2-dihydroquinoline-3-carboxamide;N-(Benzo[d][1,3]dioxol-5-ylMethyl)-7-Methoxy-2-oxo-8-(pentyloxy)-1,2-dihydro-quinolin-3-carboxaMide
- CBNumber:
- CB9829695
- Summenformel:
- C24H26N2O6
- Molgewicht:
- 438.47
- MOL-Datei:
- 282089-49-0.mol
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JTE 907 Eigenschaften
- Siedepunkt:
- 704.2±60.0 °C(Predicted)
- Dichte
- 1.267±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥10mg/mL
- Aggregatzustand
- Powder
- pka
- 9.49±0.70(Predicted)
- Farbe
- white to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher |
Xn |
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R-S?tze: |
22 |
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WGK Germany |
3 |
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RTECS-Nr. |
VB1150900 |
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Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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Sicherheit |
P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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JTE 907 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
JTE-907 is a selective peripheral cannabinoid (CB
2) receptor agonist with K
d values of 25 and 2,370, 1.55 and 1,060, and 0.38 and 1,050 nM for human, mouse, and rat CB
2 and CB
1 receptors, respectively. It increases forskolin-stimulated cAMP production in CHO cells expressing human and mouse CB
2 in a dose-dependent manner.
In vivo, JTE-907 inhibits carrageenin-induced edema in mouse paws with an ED
50 value of 0.05 mg/kg. JTE-907 also inhibits spontaneous scratching in a mouse model of chronic dermatitis at doses of 1 and 10 mg/kg.
Verwenden
Potent and selective ligands for cannabinoid type 2 receptors (CB2Rs) may have therapeutic potential for treating CB2Rs related inflammatory diseases (1). JTE 907 is a selective cannabinoid CB2 receptor inverse agonist with anti-inflammatory properties (2,3). Synthetic cannabinoids
Biologische Aktivit?t
Highly selective cannabinoid CB 2 receptor inverse agonist. Binds with high affinity to rat, mouse and human CB 2 receptors (K i values are 0.38, 1.55 and 35.9 nM respectively). Produces anti-inflammatory effects in vivo .
JTE 907 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
JTE 907 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 53)Lieferanten
- JTE 907
- N-(1,3-BENZODIOXOL-5-YLMETHYL)-1,2-DIHYDRO-7-METHOXY-2-OXO-8-(PENTYLOXY)-3-QUINOLINECARBOXAMIDE
- N-(Benzo[d][1,3]dioxol-5-ylMethyl)-7-Methoxy-2-oxo-8-(pentyloxy)-1,2-dihydro-quinolin-3-carboxaMide
- N-(benzo[d][1,3]dioxol-5-ylMethyl)-7-Methoxy-2-oxo-8-(pentyl
- 3-QuinolinecarboxaMide,N-(1,3-benzodioxol-5-ylMethyl)-1,2-dihydro-7-Methoxy-2-oxo-8-(pentyloxy)-
- JTE907
(JTE-907
- N-(benzo[d][1,3]dioxol-5-ylmethyl)-7-methoxy-2-oxo-8-(pentyloxy)-1,2-dihydroquinoline-3-carboxamide
- JTE-907, 10 mM in DMSO
- 282089-49-0