(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Ro 60-0175 is an agonist of the serotonin (5-HT) receptor subtype 5-HT₂ that stimulates increases in intracellular calcium levels in CHO-K1 cells expressing human 5-HT_2A, 5-HT_2B, and 5-HT_2C receptors (EC₅₀s = 447, 0.9, and 32 nM, respectively). It is selective for human 5-HT_2A and 5-HT_2C (K_is = 32 and 1 nM, respectively) over human 5-HT_1A, 5-HT_1D, 5-HT₆, and 5-HT₇, rat 5-HT_1B and 5-HT₃, and guinea pig 5-HT₄ receptors (K_is = ≥1,995 nM), as well as adenosine A₁ and A₂, histamine H_1-3, dopamine D_1-5, α₁-, α₂-, and β₁-adrenergic, M_1-5 muscarinic, nicotinic, kainate, AMPA, and μ-, δ-, and κ-opioid receptors (IC₅₀s = >1,000 nM), but does bind to β₂-adrenergic receptors (IC₅₀ = 251 nM). In vivo, Ro 60-0175 increases plasma levels of corticosterone, oxytocin, and prolactin in rats (ED₅₀s = 2.43, 4.19, and 4.03 mg/kg, respectively), effects that are not inhibited by the 5-HT_2C antagonist SB-242084 or the 5-HT_2A antagonist MDL 100,907 (volinanserin; ).

Verwenden

Ro 60-0175 fumarate is a potent and selective SR-2 agonist.

Biologische Aktivit?t

Potent, selective 5-HT 2 receptor agonist; shows selectivity for the 5-HT 2C subtype (pK i values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT 2C , 2A , 1A , 6 and 7 receptors respectively). Centrally active following oral or systemic administration in vivo .

(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Shanghai Anhua Biotechnology Co., Ltd.	021-61263375 18168859245		China	5958	58
Wuxi maimo topp biotechnology co., LTD	15861600115	lisa-li@mimotopes.cn	China	5829	58

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• RO 60-0175 FUMARATE
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• (AS)-6-CHLORO-5-FLUORO-ALPHA-METHYL-1H-INDOLE-1-ETHANAMINE FUMARATE
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