NH125
|
|
|
- CAS-Nr.
- 278603-08-0
- Englisch Name:
- NH125
- Synonyma:
- NH125 USP/EP/BP;EEF-2 KINASE INHIBITOR;eEF-2 Kinase Inhibitor, NH125;3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide;1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazoliumiodide;eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem;NH 125,Calmodulin-dependent protein kinases,NH-125,Calmodulin-dependent kinases,NH125,Inhibitor,Autophagy,inhibit,Fungal,Virus Protease,Bacterial,CaMK
- CBNumber:
- CB9503988
- Summenformel:
- C27H45N2.I
- Molgewicht:
- 524.567
- MOL-Datei:
- 278603-08-0.mol
|
NH125 Eigenschaften
- Schmelzpunkt:
- 88.2-94.9 °C
- storage temp.
- -20°C
- L?slichkeit
- DMSO: 20 mg/mL
- Aggregatzustand
- solid
- Farbe
- white to off-white
NH125 Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
NH125 is an inhibitor of multiple kinases. It kills methicillin-resistant Staphylococcus.
Biologische Aktivit?t
Histidine protein kinase and eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC 50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Exhibits anticancer activity in a variety of malignant cell lines (IC 50 values are 0.7 - 4.8 μ M) and blocks G 1 /S cell cycle progression. Also is an effective antibacterial agent in vitro (IC 50 = 6.6 μ M) and in vivo .
Biochem/physiol Actions
NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase.
NH125 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
NH125 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 63)Lieferanten
278603-08-0()Verwandte Suche:
- 1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazoliumiodide
- eEF-2 Kinase Inhibitor, NH125
- eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem
- EEF-2 KINASE INHIBITOR
- NH125 USP/EP/BP
- 3-Benzyl-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide
- NH 125,Calmodulin-dependent protein kinases,NH-125,Calmodulin-dependent kinases,NH125,Inhibitor,Autophagy,inhibit,Fungal,Virus Protease,Bacterial,CaMK
- 278603-08-0
- C27H45IN2
- Inhibitors
