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Nateglinide

Nateglinide Struktur
105816-04-4
CAS-Nr.
105816-04-4
Englisch Name:
Nateglinide
Synonyma:
STARLIX;N-(Trans-4-Isopropylcyclohexyl-1-Carbonyl)-D-Phenylalamine;ay4166;A-4166;Fastic;Glinate;DJN 608;Starsis;Natelide;Fastic-d5
CBNumber:
CB9472923
Summenformel:
C19H27NO3
Molgewicht:
317.42
MOL-Datei:
105816-04-4.mol

Nateglinide Eigenschaften

Schmelzpunkt:
137-141°C
alpha 
D20 -9.4° (c = 1 in methanol)
Siedepunkt:
527.6±39.0 °C(Predicted)
Dichte
1.104±0.06 g/cm3(Predicted)
storage temp. 
room temp
L?slichkeit
DMSO: >5mg/mL
pka
3.61±0.10(Predicted)
Aggregatzustand
solid
Farbe
white to off-white
Merck 
14,6428
CAS Datenbank
105816-04-4(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
S-S?tze: 24/25-36
WGK Germany  3
RTECS-Nr. SQ7318950
HS Code  29242990
Toxizit?t LD50 orally in rats: >2.0 g/kg (Hasegawa)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P281 Vorgeschriebene pers?nliche Schutzausrüstung verwenden.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Nateglinide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Nateglinide is a N-acylated D-phenylalanine marketed in Japan as novel orally active insulinotropic agent for the treatment of type-2 diabetes mellitus. It belongs to the class of nonsulfonylureas and shows some structural similarity to repaglinide, the only other representative in this family. In single pancreatic beta-cells isolated from rats, Nateglinide was found to specifically block the ATP-sensitive K+ channel resulting in an increase in intracellular calcium concentration. This primary action would underlie the mechanism by which Nateglinide markedly stimulates or potentiates, depending on glucose concentrations, insulin secretion from pancreatic beta-cells. Clinical studies demonstrated a good safety profile with a low potential for hypoglycemia. The pharmacokinetic profile was consistent with the changes of the blood glucose and plasma insulin level. Interestingly, Nateglinide exerts a rapid onset and short duration of action due to a rapid absorption and clearance. Unlike other similar agents, Nateglinide suppresses postprandial glucose elevations.

Chemische Eigenschaften

Cyrstalline Solid

Definition

ChEBI: An N-acyl-D-phenylalanine resulting from the formal condensation of the amino group of D-phenylalanine with the carboxy group of trans-4-isopropylcyclohexanecarboxylic acid. An orally-ad inistered, rapidly-absorbed, short-acting insulinotropic agent, it is used for the treatment of type 2 diabetes mellitus.

Allgemeine Beschreibung

Although nateglinide, N-(4-isopropylcyclohexanecarbonyl)-D-phenylalanine (Starlix), belongs tothe metaglinides, it is a phenylalanine derivative and representsa novel drug in the management of type 2 diabetes.

Mechanism of action

Approved in the United States in late 2000, nateglinide is a rapidly absorbed insulin secretagogue that has a mechanism of action similar to that of repaglinide, with effects appearing within 20 minutes following oral dosing. Bioavailability is 73%, and it is 98% protein bound, primarily to albumin. Nateglinide is tissue selective, with low affinity for cardiac and skeletal muscle.

Stoffwechsel

It is metabolized in the liver, with 16% excreted in the urine unchanged. The major metabolites are hydroxyl derivatives (CYP2C9, 70%; CYP3A4, 30%) that are further conjugated to the glucuronide derivatives.

Nateglinide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Nateglinide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 478)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18151 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
+8615350851019
admin@86-ss.com China 1001 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 296 58
Shanghai Arbor Chemical Co., Ltd.
021-60451682
act@arborchemical.com CHINA 904 58

105816-04-4()Verwandte Suche:


  • (-)-n-(trans-4-isopropylcyclohexanecarbonyl)-d-phenylalanine
  • ay4166
  • Nateglinide(H)
  • trans-d-phenylalanin
  • trans-d-phenylalanine
  • NATAGLINIDE
  • Nateglinide (200 mg)
  • Glinate
  • Natelide
  • AY 4166-d5
  • DJN 608-d5
  • D-Nateglinide-d5
  • Fastic-d5
  • Glinate-d5
  • N-[[trans-4-(1-Methylethyl)cyclohexyl]carbonyl]-D-phenylalanine-d5
  • Natelide-d5
  • SDZ-DJN 608-d5
  • Senaglinide-d5
  • Starlix DS-d5
  • Starlix-d5
  • Starsis-d5
  • Nateglinide (Starlix)
  • Nateglinide(A-4166)
  • (R)-2-((1r,4R)-4-isopropylcyclohexanecarboxamido)-3-phenylpropanoic acid
  • Nateglinide(3-Phenyl-2-(4-propan-2-ylcyclohexyl)carbonylamino-propanoicacid)
  • Fastic, N-[(trans-4-Isopropylcyclohexyl)carbonyl]-D-phenylalanine, Starlix, Starsis
  • N-(4α-Isopropylcyclohexane-1β-yl)carbonyl-D-phenylalanine
  • N-[[4α-(1-Methylethyl)cyclohexan-1β-yl]carbonyl]-D-phenylalanine
  • N-[[4β-(1-Methylethyl)cyclohexan-1α-yl]carbonyl]-D-phenylalanine
  • Nateglinide Solution, 100ppm
  • trans-n-((4-(1-methylethyl)cyclohexyl)carbonyl)-d-phenylalanine
  • 3-phenyl-2-(4-propan-2-ylcyclohexyl)carbonylamino-propanoic acid
  • A-4166
  • N-[[TRANS-4-(1-METHYLETHYL)CYCLOHEXYL]CARBONYL]-D-PHENYLALANINE
  • NATEGLINIDE
  • Nagteglinide
  • Nagelienai nateglinide
  • Nateglinide intermediate
  • N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylamine
  • Starlix, A-4166, N-[[trans-4-(1-methylethyl)cyclohexyl]carbonyl]-D-phenylalanine,
  • H-TYPE NATEGLINIDE
  • N-(TRANE-4-ISO-PROPYLCYLOLOHEXYLCARBOXYL)-D-PHENYLPROPYLICACID(NATEGLINIDE)
  • DJN 608
  • D-Nateglinide
  • D-Phenylalanine, N-[[4-(1-methylethyl)cyclohexyl]carbonyl]-, trans-
  • D-Phenylalanine, N-[[trans-4-(1-methylethyl)cyclohexyl]carbonyl]- (9CI)
  • Fastic
  • SDZ-DJN 608
  • Senaglinide
  • Starlix DS
  • Starsis
  • n-(trans-4-Isopropylcylolohexylcarboxyl)-d-phenylpropylicacid
  • N-[[4-(1-Methylethyl)cyclohexyl]carbonyl]-D-phenylalanine
  • (2R)-2-[[oxo-(4-propan-2-ylcyclohexyl)methyl]amino]-3-phenylpropanoic acid
  • Nateglinide 105816-04-4 CAS NO.105816-04-4
  • Nateglinide, 98%, an insulin secretagog agent
  • Nateglinide RS
  • Nateglinide>
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