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Gap19

Gap19 Struktur
1507930-57-5
CAS-Nr.
1507930-57-5
Englisch Name:
Gap19
Synonyma:
Gap19;KQIEIKKFK;L-Lysine, L-lysyl-L-glutaminyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-;myocardial,Gap19,cytoplasmic,Cx40/pannexin-1,inhibit,Gap Junction Protein,C-terminus,Gap 19,hemichannel,Inhibitor,loop,Gap-19,Cx43,channels,connexin;(2S,5S,8S,11S,14S,17S)-17-((2S,3S)-2-((S)-5-Amino-2-((S)-2,6-diaminohexanamido)-5-oxopentanamido)-3-methylpentanamido)-2,8,11-tris(4-aminobutyl)-5-benzyl-14-((S)-sec-butyl)-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaicosane-1,20-dioic acid;(2S,5S,8S,11S,14S,17S)-17-((2S,3S)-2-((S)-5-Amino-2-((S)-2,6-diaminohexanamido)-5-oxopentanamido)-3-methylpentanamido)-2,8,11-tris(4-aminobutyl)-5-benzyl-14-((S)-sec-butyl)-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaicosane-1,20-dioic acid , Gap19
CBNumber:
CB94632530
Summenformel:
C55H96N14O13
Molgewicht:
1161.46
MOL-Datei:
1507930-57-5.mol

Gap19 Eigenschaften

Siedepunkt:
1511.4±65.0 °C(Predicted)
Dichte
1.212±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
≥58.07 mg/mL in H2O; insoluble in EtOH; ≥26.55 mg/mL in DMSO
Aggregatzustand
powder
pka
3.30±0.10(Predicted)
Farbe
white to off-white
Wasserl?slichkeit
Soluble to 2 mg/ml in water

Sicherheit

Gap19 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Gap19 is a short peptide that inhibits hemichannels specifically for connexin-43 (Cx43), a cardiac connexin involved with gap junction formation. Gap junctions facilitate the exchange of ions and metabolites between cytoplasm and extracellular milieu. Reagents that inhibit hemichannels may have cardioprotective properties.

Biochem/physiol Actions

Gap19, nonapeptide from the cytoplasmic loop of Connexin-43, is a selective blocker of connexin 43 (Cx43) hemichannel that does not block GJ or Cx40/Panx-1 channels in cardiomyocytes and astrocytes. Gap19 prevents Cx43 hemichannel opening and protect against myocardial ischemia/reperfusion injury.

Gap19 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Gap19 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 55)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715
 admin@nexconn.com China 10311 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30238 58
BOC Sciences 		16314854226; +16314854226
 inquiry@bocsci.com United States 19741 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10473 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Nanjing TGpeptide 		+86-13347807150 +86-13347807150
 support@tgpeptide.com China 3279 58
Sichuan Jisheng Biopharmaceutical 		+86-0833-2598903 +8619981963231
 jane@jsjpharm.cn China 175 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Changsha MOL Changes Biotechnology Co., Ltd. 		+8619375158599
 info@molchanges.com China 5223 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185
 sales-cpd@caerulumpharma.com China 3466 58
  • Gap19
  • L-Lysine, L-lysyl-L-glutaminyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-
  • myocardial,Gap19,cytoplasmic,Cx40/pannexin-1,inhibit,Gap Junction Protein,C-terminus,Gap 19,hemichannel,Inhibitor,loop,Gap-19,Cx43,channels,connexin
  • KQIEIKKFK
  • (2S,5S,8S,11S,14S,17S)-17-((2S,3S)-2-((S)-5-Amino-2-((S)-2,6-diaminohexanamido)-5-oxopentanamido)-3-methylpentanamido)-2,8,11-tris(4-aminobutyl)-5-benzyl-14-((S)-sec-butyl)-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaicosane-1,20-dioic acid , Gap19
  • (2S,5S,8S,11S,14S,17S)-17-((2S,3S)-2-((S)-5-Amino-2-((S)-2,6-diaminohexanamido)-5-oxopentanamido)-3-methylpentanamido)-2,8,11-tris(4-aminobutyl)-5-benzyl-14-((S)-sec-butyl)-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaicosane-1,20-dioic acid
  • 1507930-57-5
  • C55H96N14O13
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