SR-95531
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- CAS-Nr.
- 104104-50-9
- Englisch Name:
- SR-95531
- Synonyma:
- GABAZINE;SR-95531;GABAZINE BROMIDE;SR 95531 hydrobromid;SR 95531 HYDROBROMIDE;Gabazine Hydrobromide;SR 95531 hydrobromide NEW;Gabazine bromide (SR95531);4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM
- CBNumber:
- CB9356638
- Summenformel:
- C15H18BrN3O3
- Molgewicht:
- 368.23
- MOL-Datei:
- 104104-50-9.mol
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SR-95531 Eigenschaften
- Schmelzpunkt:
- 200 °C(Solv: ethanol (64-17-5))
- storage temp.
- Store at RT
- L?slichkeit
- DMSO: 30 mg/mL
- Aggregatzustand
- solid
- Farbe
- white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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SR-95531 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
SR 95531 is a derivative of γ-
aminobutyric acid (GABA) that acts as an antagonist of GABA
A receptors (K
i = 74-
150 nM). When administered intravenously, it elicits seizures in mice. SR 95531 differs in action from bicuculline in that it antagonizes GABA-
induced chloride currents but not those induced by pentobarbitone. It is effective against GABA
A receptor isoforms from mice, rats, and humans.
Verwenden
Gabazine Hydrobromide is a specific GABA receptor antagonist. Does not affect GABA-transaminase or glutamate-decarboxylase activitites.
Biologische Aktivit?t
Selective, competitive GABA A receptor antagonist. Displaces [ 3 H]-GABA from rat brain membranes with a K i of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl - currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.
SR-95531 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SR-95531 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 92)Lieferanten
- Gabazine, 2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide
- 1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide
- 6-Amino-5-methyl-3-(4-methoxyphenyl)-1-pyridaziniumbutyric acid br
- 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid monohydrobromide
- Gabazine Hydrobromide
- 4-(6-Imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl)butanoic acid hydrobromide
- GABAZINE BROMIDE
- 2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM
- 2-(3-CARBOXYPROPYL)-3-AMINO-6-(4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE
- 6-IMINO-3-(4-METHOXYPHENYL)-1(6H)-PYRIDAZINEBUTANOIC ACID HYDROBROMIDE
- SR 95531 HYDROBROMIDE
- SR-95531
- SR 95531 hydrobromide NEW
- SR 95531 hydrobromid
- Gabazine bromide (SR95531)
- 4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid
- GABAZINE
- Inhibitor,Gamma-aminobutyric acid Receptor,Gabazine,γ-Aminobutyric acid Receptor,inhibit,SR 95531,GABA Receptor,SR-95531
- 104104-50-9
- 104105-50-9
- C15H17N3O3HBr
- C15H18BrN3O3
- C15H18N3O3Br
- Cell Biology
- Cell Signaling and Neuroscience
- BioChemical
- Ion Channels
- Ligand-Gated Ion Channels
- GABA and Glycine Receptor Modulators
- GABA/Glycine receptor
