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Florbenazine

Florbenazine Struktur
937245-42-6
CAS-Nr.
937245-42-6
Englisch Name:
Florbenazine
Synonyma:
Florbenazine;(2R,3R,11bR)-9-(3-fluoropropoxy)-3-isobutyl-10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol;2H-Benzo[a]quinolizin-2-ol, 9-(3-fluoropropoxy)-1,3,4,6,7,11b-hexahydro-10-methoxy-3-(2-methylpropyl)-, (2R,3R,11bR)-
CBNumber:
CB93166380
Summenformel:
C21H32FNO3
Molgewicht:
365.48
MOL-Datei:
937245-42-6.mol

Florbenazine Eigenschaften

Siedepunkt:
496.0±45.0 °C(Predicted)
Dichte
1.14±0.1 g/cm3(Predicted)
pka
14.75±0.40(Predicted)
InChI
InChI=1S/C21H32FNO3/c1-14(2)9-16-13-23-7-5-15-10-21(26-8-4-6-22)20(25-3)11-17(15)18(23)12-19(16)24/h10-11,14,16,18-19,24H,4-9,12-13H2,1-3H3/t16-,18-,19-/m1/s1
InChIKey
GNKGXQHHUUEYQV-BHIYHBOVSA-N
SMILES
C12=CC(OC)=C(OCCCF)C=C1CCN1[C@]2([H])C[C@@H](O)[C@H](CC(C)C)C1

Sicherheit

Florbenazine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Florbenazine (AV-133) is a fluorinated VMAT-2 ligand for PET. It is designed to measure dopaminergic degeneration by in vivo assessment of striat VMAT2 density in patients with Parkinson’s disease (PD). Besides differentiating PD from essential tremor and drug-induced parkinsonism, PET imaging of VMAT2 may help in differentiating Dementia with Lewy Bodies (DLB) from Alzheimer’s disease. AV-45 (florbetapir, AmyvidTM) is the first PET ligand to receive US FDA approval to assess neuritic plaque amyloid[1-2].

Florbenazine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Florbenazine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 6)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
Shanghai Chaolan Chemical Technology Center 021-QQ:65489617 15618227136
Sales@ATKchemical.com China 9342 58
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. 027-65388397 18164111589
3321478047@qq.com China 2008 55
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720
lucy@atkchemical.com China 10123 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 025-66061636 18013972705
qqyang@aikonchem.com China 10152 58

  • (2R,3R,11bR)-9-(3-fluoropropoxy)-3-isobutyl-10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol
  • Florbenazine
  • 2H-Benzo[a]quinolizin-2-ol, 9-(3-fluoropropoxy)-1,3,4,6,7,11b-hexahydro-10-methoxy-3-(2-methylpropyl)-, (2R,3R,11bR)-
  • 937245-42-6
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