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Quininib

Quininib Struktur
143816-42-6
CAS-Nr.
143816-42-6
Englisch Name:
Quininib
Synonyma:
Quininib;Quininib >=98% (HPLC);(E)-2-(2-(quinolin-2-yl)vinyl)phenol;2-[(1E)-2-(2-quinolinyl)ethenyl]-phenol;Phenol, 2-[(1E)-2-(2-quinolinyl)ethenyl]-
CBNumber:
CB93152723
Summenformel:
C17H13NO
Molgewicht:
247.29
MOL-Datei:
143816-42-6.mol

Quininib Eigenschaften

storage temp. 
Store at -20°C
L?slichkeit
DMSO: soluble
Aggregatzustand
A crystalline solid

Sicherheit

Quininib Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Quininib is an antagonist of the cysteinyl leukotriene 1 (CysLT1) and CysLT2 receptors (IC50s = 1.4 and 52 μM, respectively). It inhibits tubule formation in HMEC-1 cells when used at concentrations of 3.16 and 10 μM and inhibits sprout formation in isolated mouse aortic rings in an ex vivo model of angiogenesis when used at 10 μM. Quininib (3 μM) decreases angiogenesis in an oxygen-induced retinopathy mouse model of ocular angiogenesis, preventing revascularization when used at concentrations of 0.5 and 3 μM, as well as increasing neovascularization and vascular density when used at 3 μM. It reduces tumor growth and inhibits angiogenesis in an HT-29 colorectal cancer mouse xenograft model when administered at a dose of 50 mg/kg every three days.

Verwenden

Quininib is a novel regulator of Ocular Angiogenesis, significantly inhibiting angiogenic tubule formation in HMEC-1 cells, angiogenic sprouting in aortic ring explants and retinal revascularisation in OIR mice.

Quininib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Quininib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 19)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
isunpharm@qq.com China 4674 55
ShangHai Angti Biotechnology Co., Ltd. 13764913901
info@angtibio.com China 5037 55
ATK CHEMICAL COMPANY LIMITED 021-51619050 13301662590
mandy@atkchemical.com China 10199 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9806 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6777 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11218 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
order@med-bio.cn China 8140 58
Energy Chemical 021-58432009 400-005-6266
marketing@energy-chemical.com China 44918 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369
3477467573@qq.com China 8617 58

  • Quininib
  • (E)-2-(2-(quinolin-2-yl)vinyl)phenol
  • Phenol, 2-[(1E)-2-(2-quinolinyl)ethenyl]-
  • Quininib >=98% (HPLC)
  • 2-[(1E)-2-(2-quinolinyl)ethenyl]-phenol
  • 143816-42-6
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