FK-506-13C-d2 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

FK-506-¹³C-d₂ contains two deuterium atoms located on the carbon-13 bond. It is intended for use as an internal standard for the quantification of FK-506 by GC- or LC-MS. FK-506 is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. Its mechanism of action involves the formation of a high affinity complex (K_i = 0.2 nM) with FK-506 Binding Protein 12 (FKBP12). This complex then inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T cell activation. The physiological effects of FK-506 also include regulation of nitric oxide neurotoxicity, neurotransmitter release, and regulation of Ca²⁺ release via the ryanodine and inositol-(1,4,5)-trisphosphate (IP₃) receptors. In the latter case, FKBP12 forms a tight complex with both ryanodine and IP₃ receptors which can be disrupted by FK-506, thereby rendering the receptors “l(fā)eaky” to Ca²⁺.

Allgemeine Beschreibung

This stable-labeled internal standard is suited for quantitation of tacrolimus by LC/MS or GC/MS for clinical toxicology, therapeutic drug monitoring, or isotope dilution methods. Tacrolimus, also known as FK-506 or fujimycin, is an immunosuppressive drug marketed as Prograf, Advagraf, and Protopic usually used to prevent rejection of organ transplants and treatment of eczema. Use of a stable-labeled analog of tacrolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.

FK-506-13C-d2 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

FK-506-13C-d2 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
SIMSON PHARMA LIMITED	+91-8291074273	k.das@simsonpharma.com	India	228	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Guangzhou CATO Research Chemicals Inc.	+86-020-81960175-617 +8615602392859	Intermediate@cato-chem.com	China	8322	58
Shanghai Kewel Chemical Co., Ltd.	021-64609169 18901607656	greensnown@163.com	China	9906	50
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Artis Biotech Co. Ltd.	0575-18780151478 18582380095	sales@artisbio.com	China	3212	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Cato Research Chemicals Inc.	020-81215950 4000-868-328	customer@uwalab.com	United States	10404	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	info@synzest.com	China	9286	58

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• (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl-3-¹³C-d₂)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
• Tacrolimus-¹³C
• Tacrolimus-13C,D2 solution
• TACROLIMUS (13C, 99%
• FK-506-13C,D2 (Major) (Tacrolimus) (>
• (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl-3-13C-d2)-
• FK-506-13C,D2 (Major) (Tacrolimus)(>85%)
• D2, 98%) 100 UG/ML IN ACETONITRILE
• Tacrolimus 13CD2Q: What is Tacrolimus 13CD2 Q: What is the CAS Number of Tacrolimus 13CD2 Q: What is the storage condition of Tacrolimus 13CD2 Q: What are the applications of Tacrolimus 13CD2
• Fujimycin-13C,D2 Tacrolimus-13C D2 FK-506-13C,D2
• Tacrolimus-13C, D2 (major)
• Methadone Hydrochloride Impurity 9
• (1R,9S,12S,13R,14S,17S,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-[(3-13C,3,3-2H?)prop-2-en-1-yl]-11,28-dioxa-4-azatricyclo[22.3.1.0?,?]octacos-18-ene-2,3,10,16-tetrone
• 1356841-89-8
• C44H67D2NO12
• C43CH67D2NO12