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Larotrectinib Sulfate

Larotrectinib Sulfate Struktur
1223405-08-0
CAS-Nr.
1223405-08-0
Englisch Name:
Larotrectinib Sulfate
Synonyma:
LOX-101;Loxo-101（S）;LOX-101(sulfate);ARRY 470) sulfate;Larotinib sulfate;LOXO-101 (sulfate);Larotrectinib sulfate;Larotrectinib(LOXO 101;Larotrectinib sulphate;ARRY-470, Larotrectinib
CBNumber:
CB93067010
Summenformel:
C21H24F2N6O6S
Molgewicht:
526.52
MOL-Datei:
1223405-08-0.mol

Larotrectinib Sulfate Eigenschaften

storage temp. 
Store at -20°C
L?slichkeit
≥18.47 mg/mL in DMSO; ≥2.14 mg/mL in EtOH; ≥29.65 mg/mL in H2O
Aggregatzustand
solid
Farbe
Light yellow to brown
Stabilit?t:
Hygroscopic
InChIKey
PXHANKVTFWSDSG-RZOMTXEQNA-N
SMILES
S(O)(O)(=O)=O.FC1C=CC(F)=CC=1[C@H]1CCCN1C1C=CN2N=CC(NC(N3C[C@@H](O)CC3)=O)=C2N=1 |&1:13,29,r|
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Larotrectinib Sulfate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

LOXO-101 (sulfate) (or Larotrectinib Sulfate)  is an oral potent and selective ATP-competitive inhibitor of tropomyosin receptor kinases (TRK). 

Verwenden

Larotrectinib Sulfate is a potent and selective oral ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).

Mechanism of action

Larotrectinib sulfate functions as an inhibitor of TRKs including TRKA, B, and C. In in vitro and in vivo tumor models, larotrectinib demonstrated anti-tumor activity in cells with constitutive activation of TRK proteins resulting from gene fusions, deletion of a protein regulatory domain, or in cells with TRK protein overexpression. Larotrectinib had minimal activity in cell lines with point mutations in the TRKA kinase domain, including the clinically identified acquired resistance mutation, G595R. Point mutations in the TRKC kinase domain with clinically identified acquired resistance to larotrectinib include G623R, G696A, and F617L.

Larotrectinib Sulfate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

4H-Pyrazolo[1,5-a]pyrimidin-5-one (S)-3-Hydroxypyrrolidine 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole 3-nitropyrazolo[1,5-a]pyrimidin-5(4H)-one LOXO-101 (S)-3-Hydroxypyrrolidine hydrochloride (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine (2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE 2-Brom-1,4-difluorbenzol

Downstream Produkte

Larotrectinib Sulfate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 185)Lieferanten
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  • LOXO-101 (sulfate)
  • (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide sulfate (1:1)
  • Larotrectinib/LOXO 101/ARRY 470 sulfate
  • (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide sulfate
  • ARRY 470) sulfate
  • Larotrectinib sulfate
  • Larotrectinib(LOXO 101
  • Larotrectinib (LOXO-101) sulfate
  • 1-Pyrrolidinecarboxamide, N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-, (3S)-, sulfate (1:1)
  • ARRY-470, Larotrectinib
  • LOX-101
  • Loxo-101（S）
  • LOX-101(sulfate)
  • Larotrectinib sulfate（LOXO101）
  • (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate
  • Larotrectinib sulfate salt
  • 2H4]-Larotrectinib sulfate salt
  • LOXO-101 sulfate|||Larotrectinib (LOXO-101) sulfate|||Larotrectinib|||LOXO-101 (sulfate)|||ARRY-470|||ARRY-470 (sulfate)
  • Larotinib sulfate
  • Larotrectinib sulfate, 10 mM in DMSO
  • Larotrectinib sulphate
  • 1223405-08-0
  • C21H22F2N6O2H2SO4
  • C21H24F2N6O6S
  • API
  • LOXO-101
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