Pyridoxamindihydrochlorid
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Pyridoxamindihydrochlorid Eigenschaften
- Schmelzpunkt:
- 224-226 °C (dec.)(lit.)
- Dichte
- 1.4025 (rough estimate)
- Brechungsindex
- 1.6100 (estimate)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- Powder or Solid
- pka
- pKa 3.31(H2O t = 25 I = 0.1)(Approximate)
- Farbe
- White to off-white to pale brown
- Wasserl?slichkeit
- Soluble in DMSO, water, or methanol /n
- Merck
- 7980
- BRN
- 3632748
- CAS Datenbank
- 524-36-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xi | ||
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R-S?tze: | 36/37/38 | ||
S-S?tze: | 26-36 | ||
WGK Germany | 2 | ||
RTECS-Nr. | UV1230000 | ||
HazardClass | IRRITANT | ||
HS Code | 29333990 | ||
Toxizit?t | cat,LD50,intravenous,540mg/kg (540mg/kg),GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDSBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 922, 1961. |
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Pyridoxamindihydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Pyridoxamine dihydrochloride is a salt and amine form of pyridoxamine, which belongs to the family of vitamin B6 compounds. Pyridoxamine occurs naturally in animal-based food products. Its deficiency in humans potentially causes sideroblastic anemia, weakness, insomnia, and neurological disorders. It has been reported to be effective against diabetic nephropathy. Pyridoxamine dihydrochloride acts as a catalyst in the metabolism of fats, carbohydrates, and proteins in the body, thereby assisting in maintaining energy balance in kidney disease patients.Chemische Eigenschaften
It is a white to yellowish crystal or crystalline powder that readily absorbs moisture. It is generally stable at room temperature but tends to change color when exposed to light. Its melting point is at 226-227℃, with decomposition. It exhibits maximum absorption at a wavelength of 287.5nm. The substance is soluble in water, slightly soluble in ethanol, but insoluble in ether or chloroform.Verwenden
Pyridoxamine dihydrochloride (Pyridorin, NephroGenex, 524-36-7) inhibits formation of advanced glycation end products and scavenges reactive oxygen species and toxic carbonyls. Whether these effects translate into kidney protection is unknown, although a year-long study of the effects of pyridoxamine dihydrochlo-ride in patients with type 2 diabetes and proteinuria failed to show a difference in kidney function decline with pyri-doxamine dihydrochloride in daily doses of 300 or 600 mg versus placebo treatment.synthetische
The procedure for preparing pyridoxamine dihydrochloride involves several steps: firstly enabling pyridoxal oxime to react with acetic acid and zinc to obtain acetic acid solution containing pyridoxamine, then decompressing the solution and reclaiming the acetic acid to obtain slurry concentrate, decompressing and reclaiming the acetic acid again to obtain pyridoxamine water solution, regulating the pH value to be alkaline so as to separate pyridoxamine out, adding water and hydrochloric acid after vacuum filteration, decoloring and filtering to obtain filtrate, decompressing and concentrating the filtrate until white solids are separated out, adding solvent and stirring, and finally crystallizing at the lower temperature, filtering and drying to obtain the pyridoxamine dihydrochloride.CN101628892A
Definition
ChEBI: Pyridoxamine dihydrochloride is a hydrochloride obtained by combining pyridoxamine with two molar equivalents of hydrochloric acid. Used for treatment of diabetic nephropathy. It has a role as an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite, a human metabolite, a mouse metabolite, a plant metabolite, an iron chelator and a nephroprotective agent. It is a hydrochloride and a vitamin B6. It contains a pyridoxamine(2+).Pharmakokinetik
The progression of diabetic nephropathy can be blocked by Pyridoxamine dihydrochloride, a derivative of vitamin B6, which is a potent inhibitor of AGE formation. However, it has been observed that this treatment is only effective in patients who have relatively preserved kidney function (baseline SCr 1.3 to 1.9 mg/dL).l?uterung methode
The amine salt is crystallised from hot MeOH. The free base crystallises from EtOH with m 193-193.5o [Harris et al. J Biol Chem 154 315 1944, J Am Chem Soc 66 2088 1944]. [Beilstein 22 IV 6064, 22/12 V 324.]Pyridoxamindihydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Pyridoxamindihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 350)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12825 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5893 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21639 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32820 | 60 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3619 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29886 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10310 | 58 |
Hebei Weibang Biotechnology Co., Ltd | +8615531157085 |
abby@weibangbio.com | China | 8816 | 58 |
Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 |
sales@czwytech.com | CHINA | 904 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5906 | 58 |
524-36-7(Pyridoxamindihydrochlorid)Verwandte Suche:
Imidazolidin-2-thion
Benzamidiniumchlorid
N-(2-(Dimethylamino)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin
1,1'-Carbonylbis-1H-imidazol
Pyridoxamindihydrochlorid
3-Pyridylmethanol
Pyridoxaminphosphat
- Pyridoxamine Dihydrochloride Monohydrate
- 2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridine dihydrochloride
- Dyridoxamine hydrochloride
- Pyridoxamine·2hydrochloride
- vitamin B6dihydrochloride
- Pyridoxamine dihydrochloride,4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride
- Pyridoxamine dihydro
- 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol(SALTDATA: 2HCl)
- Pyridoxamine-[2H3] dihydrochloride
- 2-Methyl-3-hydroxy-4-aMinoMethyl-5-hydroxMethylpyridine Dihydrochloride
- PyridoxylaMine Dihydrochloride
- PyridoxaMine 2HC1
- PyridoxaMine dihydrochloride SynonyMs 4-(AMinoMethyl)-5-hydroxy-6-Methyl-3-pyridineMethanol dihydrochloride
- 4-(AMINOMETHYL)-5-HYDROXY-6-METHYL-3-PYRIDENEMETHANOL DIHYDROCHLORIDE
- 4-AMINOMETHYL-5-HYDROXY-6-METHYL-3-PYRIDINEMETHANOL DIHYDROCHLORIDE
- PYRIDOXAMINE DIHYDROCHLORIDE
- 2-methyl-3-hydroxy-4-aminomethyl-5-hydroxymethylpyridenedihydrochloride
- 4-(aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanodihydrochloride
- Pyridoxamine DiHCl
- 4-(Aminomethyl)-5-Hydroxy-6-Methyl-3-Pyridenemetha
- 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol dihydrochloride
- 4-(aminomethyl)-5-(hydroxymethyl)-2-
- PYRIDOXAMINE DIHYDROCHLORIDE, CELL*CULTU RE TESTED
- PYRIDOXAMINE 2HCL
- 4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol Dihydrochloride, 2-Methyl-3-hydroxy-4-aminomethyl-5-hydroxmethylpyridine Dihydrochloride
- PyridoxaMinetwohydrochloride
- PyridoxaMin Dihydrochloride
- 3-PyridineMethanol,4-(aMinoMethyl)-5-hydroxy-6-Methyl-, hydrochloride (1:2)
- 287091_ALDRICH
- 2-Methyl-3-hydroxy-4-aminomethyl-
- 82885_FLUKA
- NSC 21278
- P9158_SIGMA
- P9380_SIGMA
- Pyridoxamine dichlorohydrate
- PYRIDOXEMINE, DIHYDROCHLORIDE
- -2-methylpyridin-3-ol dihydrochloride
- 4-(aminomethyl)-2-methyl-5-methylol-pyridin-3-ol dihydrochloride
- 4-(aminomethyl)-5-(hydroxymethyl)-2-methyl-3-pyridinol dihydrochloride
- Pyridoxamine, Dihydrochloride - CAS 524-36-7 - Calbiochem
- 4-(aminomethyl)-5-(hydroxymethyl)-2-methyl-3-pyridinol
- Pyridoxamine dihydrochloride (Vitamin B6)
- Pyridoxamine Dihydrochloride Standard
- dihydrochL
- 3-Pyridinemethanol, 4-(aminomethyl)-5-hydroxy-6-methyl-,dihydrochloride
- )-5-(hydroxymethyL
- Pyridoxamine dihydrochloride USP/EP/BP
- Pyridoxamine dihydrochloride, (B6 Derivative)
- Pyridoxamine hydrochloride, 99%+
- Pyridoxamine dihydrochlorideQ: What is Pyridoxamine dihydrochloride Q: What is the CAS Number of Pyridoxamine dihydrochloride Q: What is the storage condition of Pyridoxamine dihydrochloride
- PYRIDOXAMINE HCL
- PYRIDOXAMINE
- Pyridomide hydrochloride
- Pyridoxamine, dihydrochloride (8CI)
- Pazopanib Impurity 98
- Pyridoxamine Dihydrochloride in 0.1mol/LHCl (as free base)
- 524-36-7
- C8H12N2O22HClH2O