Bulleyaconitine A Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Bulleyaconitine A is an aconitine-type two terpene alkaloid, and its molecular formula is C35H49NO10.?As early as 1980, bulleyaconitine was separated and extracted
from a traditional analgesic and anti-inflammatory herb in the west of Yunnan called
dianxi dula (or dianxi wutou) (Aconitum bulleyanum Diels), by the Kunming
Institute of Botany, Chinese Academy of Sciences . At present, bulleyaconitine A
can be separated from Aconitum plants, for example, dianxi wutou (Aconitum bulleyanum Diels), cujing wutou (Aconitum crassicaule W.T.?Wang), changhui wutou
(Aconitum georgei Comber), and zhiyuan wutou (Aconitum transsectum Diels).
Physikalische Eigenschaften
Appearance: white powder. Solubility: soluble in methanol, ethanol, chloroform,
and ether; insoluble in water; and easily dissolved in dilute hydrochloric acid or
dilute sulfuric acid . Melting point: 160–165?°C
History
In 1983, it was confirmed that bulleyaconitine A shows obvious analgesic and antiinflammatory effects by preclinical pharmacological tests . Clinical trials were
carried out in 29 hospitals in 9 provinces in 1984. Bulleyaconitine A passed technical appraisals in May 1985 and was first formally put into production by Yunnan
Honghe Pingbian pharmaceutical company, where it obtained the trade name
“Bulleyaconitine A.” Bulleyaconitine A has been listed into the Pharmacopoeia of
the People’s Republic of China (2015). In recent years, bulleyaconitine A has shown
a great market growth and competitive power, owing to its exact curative effect and
rapid clinical promotion in chronic disease and rheumatic immune disease.
Clinical Use
1. Rheumatic immune disease. Since listing, bulleyaconitine A has been applied in
clinical treatment for rheumatoid arthritis and osteoarthritis, receiving good
curative effects.
2. Chronic pain. Bulleyaconitine A does not belong to NSAID, and it exerts its
effects by regulating the sodium ion channel. So there is little psychological
dependence and organ toxicity, avoiding gastrointestinal/cardiovascular/renal
adverse reactions and drug dependence or other potential dangers caused by
NSAID and opioid analgesics.
Bulleyaconitine A Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
