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N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide

N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide Struktur
942206-85-1
CAS-Nr.
942206-85-1
Englisch Name:
N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide
Synonyma:
GSK101;CS-2774;GSK1016790A;GSK1016790A(GSK101);GSK-1016790A;GSK 1016790A;GSK1016790A, 10 mM in DMSO;GSK-1016790A, TRPV4 channel agonist;GSK1016790A;GSK-1016790A;GSK 1016790A;N-((S)-1-(4-(((2,4-dichlorophenyl)sulfonyl)-L-seryl)piperazin-1-yl)-4-methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxamide;N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide
CBNumber:
CB92676060
Summenformel:
C28H32Cl2N4O6S2
Molgewicht:
655.61
MOL-Datei:
942206-85-1.mol

N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide Eigenschaften

Schmelzpunkt:
>119°C (dec.)
Dichte
1.426±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
DMSO: >10mg/mL
Aggregatzustand
white solid
pka
8.29±0.50(Predicted)
Farbe
White to Off-White
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Sicherheit

WGK Germany  1

N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

GSK 1016790A is a transient receptor potential vanilloid 4 (TRPV4) agonist.

Biochem/physiol Actions

GSK1016790A is a novel and potent TRPV4 channel agonist. The TRPV4 (transient receptor potential vanilloid 4) member of the TRP superfamily has been implicated in numerous physiological processes. GSK1016790A elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM, respectively), and evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. It is 300 fold more potent than 4a-PDD (Cat. No. P8014).

N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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942206-85-1()Verwandte Suche:

  • N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide
  • (N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide
  • GSK1016790A
  • GSK101
  • GSK1016790A;GSK-1016790A;GSK 1016790A
  • CS-2774
  • GSK-1016790A;GSK 1016790A
  • Benzo[b]thiophene-2-carboxamide, N-[(1S)-1-[[4-[(2S)-2-[[(2,4-dichlorophenyl)sulfonyl]amino]-3-hydroxy-1-oxopropyl]-1-piperazinyl]carbonyl]-3-methylbutyl]-
  • N-((S)-1-(4-(((2,4-dichlorophenyl)sulfonyl)-L-seryl)piperazin-1-yl)-4-methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxamide
  • GSK1016790A(GSK101)
  • inhibit,Ca2+ channels,Inhibitor,embryonic,GSK-1016790A,Ca channels,HEK,vanilloid,transient,potential,receptor,TRP Channel,GSK1016790A,kidney,Calcium Channel,human,Transient receptor potential channels
  • GSK-1016790A, TRPV4 channel agonist
  • GSK1016790A, 10 mM in DMSO
  • 942206-85-1
  • C28H32Cl2N4O6S2
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