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Capmatinib

Capmatinib Struktur
1029712-80-8
CAS-Nr.
1029712-80-8
Englisch Name:
Capmatinib
Synonyma:
INC280;INCB28060;INC28060;2-Fluoro-N-Methyl-4-(7-quinolin-6-ylMethyl-iMidazo[1,2-b][1,2,4] triazin-2-yl)-benzaMide;NC280;CS-192;INCB028060;NVP-INC280;CapMatinib;Karma for,
CBNumber:
CB92574678
Summenformel:
C23H17FN6O
Molgewicht:
412.42
MOL-Datei:
1029712-80-8.mol

Capmatinib Eigenschaften

Schmelzpunkt:
>250°C (dec.)
Dichte
1.40
Dampfdruck
0-0Pa at 20-25℃
storage temp. 
-20°C Freezer, Under inert atmosphere
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
pka
13.82±0.46(Predicted)
Aggregatzustand
Solid
Farbe
Pale Yellow to Light Yellow
InChI
InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
InChIKey
LIOLIMKSCNQPLV-UHFFFAOYSA-N
SMILES
C(NC)(=O)C1=CC=C(C2=NN3C(CC4=CC=C5C(=C4)C=CC=N5)=CN=C3N=C2)C=C1F
LogP
1.6-2.2 at 35℃ and pH7-9
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Capmatinib Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Capmatinib is a competitive inhibitor with very potent and selective activity against MET compared to other kinases.

Verwenden

2-Fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide is used in the preparation of a combination formulation with allosteric SHP2 inhibitor TNO155. Used in treatment of non-small cell lung cancer with specific mutations (those that lead to mesenchymal-epithelial transition or MET exon 14 skipping).

Trademarks

Tabrecta

Nebenwirkungen

Most common adverse events were nausea, peripheral edema, decreased appetite, rash, and increased amylase and lipase levels.

Capmatinib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Benzamide, 2-fluoro-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]- 2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzoicacid Dimethylsulfat

Downstream Produkte

Capmatinib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 285)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Zhengzhou Anhuida Chemical Co., Ltd
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Nanjing Gold Pharmaceutical Technology Co. Ltd. 		025-84209270 15906146951
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32965 60
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act@arborchemical.com CHINA 904 58
TianYuan Pharmaceutical CO.,LTD 		+86-755-23284190 13684996853
sales@tianpharm.com CHINA 304 58
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Jurong Coupling Biotechnology Co., Ltd. 		13656108824
coupling278191416@hotmail.com CHINA 184 58
  • INCB028060
  • CapMatinib (INCB28060)
  • CapMatinib
  • NC280 BenzaMide,2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-
  • NVP-INC280
  • 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Capmatinib (INCB28060)
  • INCB28060, INC280
  • BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]- INCB28060
  • INC28060(BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-)
  • INC 280 (INCB28060)
  • INCB28060(Capmatinib)
  • BenzaMide INCB28060
  • BenzaMide HCl
  • CAPMATINIB (INCB28060);INCB-28060; INC-280
  • BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-
  • CS-192
  • INCB 28060; INCB-28060; INC280
  • INC280 Capmatinib
  • CAPMATINIB (INC280)
  • INCB28060,BenzaMide
  • NC280
  • 2-fluoro-n-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide capmatinib
  • Capmatinib base
  • 2-Fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
  • Capmatinib USP/EP/BP
  • INC28060
  • INCB28060
  • 2-Fluoro-N-Methyl-4-(7-quinolin-6-ylMethyl-iMidazo[1,2-b][1,2,4] triazin-2-yl)-benzaMide
  • INC280
  • Karma for,
  • Valproic Acid Impurity 69
  • Capmatinib, 10 mM in DMSO
  • 1029712-80-8
  • C23H17FN6O
  • Inhibitors
  • API
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