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[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester

[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester Struktur
353280-43-0
CAS-Nr.
353280-43-0
Englisch Name:
[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester
Synonyma:
S26948;S26948,S-26948;S 26948 >=98% (HPLC);[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester;2-[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-propanedioic acid 1,3-dimethyl ester;Propanedioic acid, 2-[[4-[2-(6-benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-, 1,3-dimethyl ester
CBNumber:
CB92518890
Summenformel:
C28H25NO7S
Molgewicht:
519.57
MOL-Datei:
353280-43-0.mol

[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester Eigenschaften

Schmelzpunkt:
65-67 °C(Solv: methanol (67-56-1))
Siedepunkt:
687.3±65.0 °C(Predicted)
Dichte
1.312±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
L?slichkeit
DMSO: soluble10mg/mL (clear solution)
Aggregatzustand
powder
pka
12.48±0.59(Predicted)
Farbe
white to beige

Sicherheit

WGK Germany  3

[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

S26948 is a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 8.83 nM in a transactivation assay). It is selective for PPARγ over PPARα, PPARβ/δ, and retinoid X receptor α (RXRα) at 10 μM. S26948 (30 mg/kg per day) decreases serum levels of glucose, triglycerides, non-esterified fatty acids, and insulin and increases hepatic palmitate oxidation in an ob/ob mouse model of type 2 diabetes. It decreases plasma levels of triglycerides and total and non-HDL cholesterol and the surface area of atherosclerotic lesions in the aortic sinus in an E2-KI transgenic mouse model of dyslipidemia and atherosclerosis fed a Western diet when administered at a dose of 30 mg/kg.

Verwenden

S26948 is a peroxisome proliferator-activated receptor γ modulator with potent antidiabetes and antiatherogenic effects.

[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 16)Lieferanten
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
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3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
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MedBioPharmaceutical Technology Inc 021-69568360 18916172912
 order@med-bio.cn China 8140 58
Energy Chemical 021-58432009 400-005-6266
 marketing@energy-chemical.com China 44918 58
TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24644 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
 customer_service@efebio.com China 11974 58
ApexBio Technology --
 sales@apexbt.com United States 6251 58
  • [[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-1,3-propanedioicaciddimethylester
  • 2-[[4-[2-(6-Benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-propanedioic acid 1,3-dimethyl ester
  • S26948
  • S 26948 >=98% (HPLC)
  • S26948,S-26948
  • Propanedioic acid, 2-[[4-[2-(6-benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-, 1,3-dimethyl ester
  • 353280-43-0
  • C28H25NO7S
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