Zanamivir-13C,15N2 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Zanamivir-
13C,
15N
2 is intended for use as an internal standard for the quantification of zanamivir by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles. It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC
50 values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC
50 values ranging from 0.6 to 7.9 nM
in vitro. Intranasal zanamivir administration at 0.4 mg/kg twice daily reduces mortality and viral titers in lung homogenates of mice infected with influenza.
Chemische Eigenschaften
White Solid
Verwenden
Influenza viral neuraminidase inhibitor; structural analog of the sialic acid. Antiviral.
Zanamivir-13C,15N2 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte