Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
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- CAS-Nr.
- 27143-07-3
- Englisch Name:
- Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
- Synonyma:
- Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate;(Z)-ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester;Ethyl(z)-2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;hydrazono);Apixaban-2;Ethyl chloro;RSYY（Avanafil)-38;RSYY（Avanafil)-43
- CBNumber:
- CB92500866
- Summenformel:
- C11H13ClN2O3
- Molgewicht:
- 256.69
- MOL-Datei:
- 27143-07-3.mol
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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Eigenschaften
- Schmelzpunkt:
- 94℃
- Siedepunkt:
- 349.0±44.0 °C(Predicted)
- Dichte
- 1.23
- storage temp.
- 2-8°C
- L?slichkeit
- Chloroform (Sparingly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 11.63±0.10(Predicted)
- Farbe
- Yellow to Dark Yellow
- InChI
- InChI=1S/C11H13ClN2O3/c1-3-17-11(15)10(12)14-13-8-4-6-9(16-2)7-5-8/h4-7,13H,3H2,1-2H3
- InChIKey
- ATNPZEGMKLGIFA-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)C(Cl)=NNC1=CC=C(OC)C=C1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P321 |
Besondere Behandlung |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Chemische Eigenschaften,Einsatz,Produktion Methoden
Physikalische Eigenschaften
Light yellow to dark yellow solid
Verwenden
Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester is an ester derivative and can be used as an intermediate in the synthesis of apixaban.
Synthese
Step-1:Water (600 ml) was added to p-anisidine (100 g) at room temperature and the resulting mixture was cooled to 10°C, followed by the addition of concentrated hydrochloric acid (133.5 g). The resulting mixture was cooled to —5°C to 0°C, followed by portion-wise addition of 40 % aqueous sodium nitrite solution over 45 minutes to 1 hour. The resulting mass was stirred for 1 hour 30 minutes at —5°C to0°C, followed by slow addition of 11 % sulfamic acid solution over 1 hour to 1 hour 30 minutes to produce a reaction mass (first part).Step-2:Sodium acetate (146 g) was added to water (300 ml) at room temperature and then stirred for 10 minutes to 15 minutes, followed by the addition of ethyl 2-chloroacetoacetate (160.4g) and acetone (300 ml) at room temperature to form a reaction mixture. The resulting mixture was cooled to 0°C. The resulting mixture was added to the reaction mass (first part) obtained in step-i at —5°C to 0°C and then stirred for 1 hour at the same temperature. Acetone (200 ml) was added to the resulting mass and stirred for 30 minutes at —5°C to 0°C. The resulting mass was settled for 5 hours at —5°C to 0°Cand then filtered the solid. Methanol (150 ml) was added to the resulting solid at room temperature and then stirred for 2 hours at the same temperature. Ethyl 2-chloro-2-(2-(4-methoxyphenyl) hydrazone)acetate was obtained through further purity.
Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 461)Lieferanten
- 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]
- (Z)- Ethyl chloro[(4-Methoxyphenyl)hydrazono]acetate
- Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester
- 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene], ethyl ester
- ethyl chloro[2-(4-Methoxyphenyl)hydrazinylidene]acetate
- thyl chloro[2-(4-methoxyphenyl)hydrazinylidene]acetate
- Chloro((4-Methoxyphenyl)hydrazone)acetic acid ethyl ester
- 1. 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene]acetic acid ethyl ester
- 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene] acetic acid, ethyl ester
- Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate
Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester
- ethyl (2Z)-2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate
- Apixaban Intermediate 1
- Ethyl 2-chloro-2-(2-(4-methoxyphenyl)
- hydrazono)
- ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate
- Apixaban Impurity B
- (Z)-Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
(Apixaban)
- Apixaban-2
- 1-(4-methoxyphenyl)-4-(2-((4-(2-oxopiperidin-1-yl)phenyl)amino)ethyl)-1H-pyrazole-3,5-dicarboxamide
- Acetic acid, chloro[(4-methoxyphenyl)hydrazono]-, ethyl ester
- ethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate，Aceticacid,2-chloro-2-[2-(4- methoxyphenyl)hydrazinylidene], ethyl ester
- Apixaban intermediates，Ethyl chloro[2-(4- methoxyphenyl)hydrazinylidene]acetate
- Apixaban ethyl chloroacetate
- Apixaban Impurity 158
- 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene] Apixaban Impurity 18
- Ethyl 2-chloro-2-(2 -(4-methoxyphenyl)hydrazono)acetate chloro ester
- ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazono]acetate
- Impurity of apixaban382
- Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl este
- Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester
- Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate
- Ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate
- (Z)-ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate
- Ethyl(z)-2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate
- Aceticacid,2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]-,ethylester,(8Z)-
- RSYY（Avanafil)-38
- RSYY（Avanafil)-43
- Ethyl [(4-methoxyphenyl)hydrazono]chloroacetate
- Ethyl chloro
- (Z)-Ethyl-2-C-2-(2-(4-Methoxy Phenyl) Hydrazone acetate
- Ethyl chloro[(4-methoxyphenyl)hydrazono]acetat
- Ethyl 2-chloro-2-[2-(4-methyoxyphenyl)hydrazono]acetate
- Apixaban Impurity 2
- 27143-07-3
- 27143-07-0
- 27143-07-2
- 27143-07-3
