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6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Struktur
1231930-33-8
CAS-Nr.
1231930-33-8
Englisch Name:
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Synonyma:
6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole;Abemaciclib Impurity 1;Abemaciclib Impurity N4;Abemaciclib Impurity 1 D5;Abemaciclib Impurity 1 D12;6-bromo-4-fluoro-2-methyl-1-(1-methylethyl)-;6-Bromo-4-fluoro-1-isopropyl-2-methylbenzimidazole;6-bromo-4-fluoro-2-methyl-1-propan-2-ylbenzimidazole;6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole;6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
CBNumber:
CB92500134
Summenformel:
C11H12BrFN2
Molgewicht:
271.13
MOL-Datei:
1231930-33-8.mol

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Eigenschaften

Siedepunkt:
353.4±22.0 °C(Predicted)
Dichte
1.49
storage temp. 
Sealed in dry,Room Temperature
pka
3.48±0.10(Predicted)
InChI
InChI=1S/C11H12BrFN2/c1-6(2)15-7(3)14-11-9(13)4-8(12)5-10(11)15/h4-6H,1-3H3
InChIKey
SJQZRZLUEGCXFN-UHFFFAOYSA-N
SMILES
C1(C)N(C(C)C)C2=CC(Br)=CC(F)=C2N=1

Sicherheit

HS Code  2933998090

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole is a pharmaceutical intermediate. It can be used in the preparation of Abemaciclib, a kinase inhibitor for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer who have experienced disease progression following endocrine therapy and prior chemotherapy.

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1H-Benzimidazole, 5-bromo-7-fluoro-2-methyl- Ethanimidamide,N-(1-methylethyl)- EthaniMidaMide, N-(4-broMo-2,6-difluorophenyl)-N'-(1-Methylethyl)- 4-Bromo-2,6-difluoroaniline N-Isopropylacetamide Aceton

Downstream Produkte

1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-

6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 224)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652
 info@fdachem.com China 20267 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21634 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32965 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29879 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63687 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366
export01@shyrchem.com CHINA 1319 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989
 contact@fuxinpharm.com China 10032 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051
 joe@yuhengpharm.com CHINA 21142 58
  • 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
  • 1H-BenziMidazole, 6-broMo-4-fluoro-2-Methyl-1-(1-Methylethyl)-
  • 6-bromo-4-fluoro-2-methyl-1-propan-2-ylbenzimidazole
  • 6-bromo-4-fluoro-2-methyl-1-(propan-2-yl)-1H-1,3-benzodiazole
  • 6-Bromo-4-fluoro-1-isopropyl-2-methylbenzimidazole
  • Abemaciclib Impurity 1
  • 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole ISO 9001：2015 REACH
  • Abemaciclib Impurity 1 D12
  • Abemaciclib Impurity 1 D5
  • 6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole
  • 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole
  • 6-bromo-4-fluoro-2-methyl-1-(1-methylethyl)-
  • 5-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
  • 5-bromo-7-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
  • Abemaciclib Impurity N4
  • 1231930-33-8
  • 1230930-33-8
  • API
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