D609 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC; K_i = 6.4 μM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA₂, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations when used at concentrations of 100 and 200 mg/ml, respectively. Similar to other xanthates, D609 has antioxidant, antiviral, and anti-tumor activities. In addition, it has anti-inflammatory actions, inhibiting LPS-stimulated expression of nitric oxide synthase (NOS) in phagocytes (IC₅₀ = 20 μg/ml) and IL-1β-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in endothelial cells.

Chemische Eigenschaften

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Verwenden

D609 has been used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor in mouse bone marrow derived monocytes. D609 has also been reported to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E^-/- mice.

Biologische Aktivit?t

Selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (K i = 6.4 μ M); antiviral and antitumor agent. Suppresses LPS- and IFN γ -induced NO production (IC 50 = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo .

D609 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

D609 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32965	60
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30236	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
Chembest Research Laboratories Limited	+86-21-20908456	sales@BioChemBest.com	China	6005	61

83373-60-8()Verwandte Suche:

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• Tricyclodecan-9-yl xanthate
• Tricyclodecan-9-yl xanthate potassium salt
• Tricyclodecan-9-yl xanthogenate
• D609 potassium salt,98%
• Carbonodithioic acid O-(octahydro-4,7-methano-1H-inden-5-yl) ester potassium salt
• tricyclodecane-9-yl-xanthogenate
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• CARBONODITHIOIC ACID, O-(OCTAHYDRO-4,7-METH
• TRICYCLODECAN-9-YL XANTHOGENATE K
• TRICYCLODECAN-9-YL XANTHOGENATE POTASSIUM SALT
• CARBONODITHIOIC ACID, O-(OCTAHYDRO-4,7-METHANO-1H-INDEN-5-YL) ESTER POTASSIUM
• D609
• D-609 POTASSIUM
• D609 POTASSIUM SALT
• O-TRICYCLO[5.2.1.0(2,6)]DEC-9-YL DITHIOCARBONATE POTASSIUM SALT
• O-(OCTAHYDRO-4,7-METHANO-1H-INDEN-5-YL) CARBONOPOTASSIUM DITHIOATE
• potassium O-(octahydro-4,7-methano-1H-inden-5-yl) dithiocarbonate
• O-TRICYCLO(5.2.1.02,6)DEC-9-YL*DITHIOCAR BONATE POTA
• Dithiocarbonic acid O-[(octahydro-4,7-methano-1H-inden)-5-yl]S-potassium salt
• D609, Potassium Salt - CAS 83373-60-8 - Calbiochem
• O-Tricyclo[5.2.1.02,6]dec-9-yl dithiocarbonate
• D609,O-(Octahydro-4,7-methano-1H-inden-5-yl)carbonopotassiumdithioate
• potassium O-(octahydro-1H-4,7-methanoinden-5-yl) carbonodithioate
• D609,D-609
• D609, 10 mM in DMSO
• 83373-60-8
• C11H15KOS2
• Biochemicals and Reagents
• BioChemical
• P to Q
• Phospholipase C, phosphatidylcholine-specific
• Enzyme Inhibitors by Enzyme
• Enzyme Inhibitors
• Enzymes, Inhibitors, and Substrates
• Lipid signaling