Lecozotan hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Treatment of cognitive deficits associated with Alzheimer’s disease (5-HT1A
receptor antagonist).
Einzelnachweise
[1] WAYNE E. CHILDERS. Synthesis and Biological Evaluation of Benzodioxanylpiperazine Derivatives as Potent Serotonin 5-HT1A Antagonists: The Discovery of Lecozotan[J]. Journal of Medicinal Chemistry, 2005, 48 10: 3467-3470. DOI:
10.1021/jm049493z.
[2] L E SCHECHTER. Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties.[J]. Journal of Pharmacology and Experimental Therapeutics, 2005, 314 3: 1274-1289. DOI:
10.1124/jpet.105.086363.
[3] KEVIN BOOTH. P3-425: Safety, tolerability and efficacy of lecozotan SR in patients with mild-to-moderate Alzheimer’s disease used as monotherapy or adjunctively with a cholinesterase inhibitor[J]. Alzheimer’s & Dementia, 2012, 8 4S_Part_16: P604. DOI:
10.1016/j.jalz.2012.05.2099.
[4] MIGUEL SKIRZEWSKI . Acute lecozotan administration increases learning and memory in rats without affecting anxiety or behavioral depression[J]. Pharmacology Biochemistry and Behavior, 2010, 95 3: Pages 325-330. DOI:
10.1016/j.pbb.2010.02.008.
Lecozotan hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
