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TENOVIN-1

TENOVIN-1 Struktur
380315-80-0
CAS-Nr.
380315-80-0
Englisch Name:
TENOVIN-1
Synonyma:
CS-571;TENOVIN-1;Tenovin-1, >=98%;TENOVIN-1;TENOVIN 1;TENOVIN-1 USP/EP/BP;Tenovin-1, p53 Activator;Tenovin-1, 10 mM in DMSO;N-[(4-acetaMidophenyl)carbaMothioyl]-4-tert-butylbenzaMide;N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide;Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-
CBNumber:
CB92446962
Summenformel:
C20H23N3O2S
Molgewicht:
369.48
MOL-Datei:
380315-80-0.mol

TENOVIN-1 Eigenschaften

Schmelzpunkt:
>180°C (Subl.)
Dichte
1.238±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
Soluble in DMSO (10 mg/ml with warming)
Aggregatzustand
solid
pka
9.09±0.70(Predicted)
Farbe
White
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

RIDADR  3077
HS Code  29242990

TENOVIN-1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Tenovin-1 is a small molecule activator of p53 transcriptional activity. At 10 μM, it elevates p53 expression in MCF-7 cells within two hours of treatment and longer-term exposure significantly decreases the growth of BL2 Burkitt’s lymphoma and ARN8 melanoma cells. Functioning upstream of p53, tenovin-1 acts by inhibiting the deacetylase activity of purified human SIRT1 and SIRT2, members of NAD+-dependent class III histone deacetylases that belong to the sirtuin family. While tenovin-1 demonstrates low genotoxicity, the compound has poor water solubility, which limits its uses in vivo.

Verwenden

Tenovin 1 is a sirtuin inhibitor.

Biologische Aktivit?t

p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21 CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro .

TENOVIN-1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

TENOVIN-1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 117)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32965 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29879 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289
 contact@trustwe.com China 5738 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 22787 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
  • TENOVIN-1
  • N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide
  • N-[(4-acetaMidophenyl)carbaMothioyl]-4-tert-butylbenzaMide
  • Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-
  • N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide Tenovin 1
  • Tenovin 1 N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide
  • Tenovin-1, >=98%
  • TENOVIN-1;TENOVIN 1
  • CS-571
  • TENOVIN-1 USP/EP/BP
  • Tenovin-1, p53 Activator
  • Tenovin-1, 10 mM in DMSO
  • 380315-80-0
  • Inhibitor
  • Inhibitors
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