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(S)-1-Boc-2-(Hydroxymethyl)piperazine

(S)-1-Boc-2-(Hydroxymethyl)piperazine Struktur
1030377-21-9
CAS-Nr.
1030377-21-9
Englisch Name:
(S)-1-Boc-2-(Hydroxymethyl)piperazine
Synonyma:
(S)-1-Boc-2-(hyroxyMethyl)piperazine;(S)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE;(S)-N1-BOC-2-Hydroxymethyl-piperazine;(2S)-2-(Hydroxymethyl)piperazine, N1-BOC protected;(S)-tert-butyl 2-(hydroxyMethyl)piperazin-1-carboxylate;(S)-tert-butyl 2-(hydroxyMethyl)piperazine-1-carboxylate;tert-butyl (S)-2-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (2S)-2-(hydroxymethyl)piperazine-1-carboxylate;1,1-Dimethylethyl (2S)-2-(hydroxymethyl)-1-piperazinecarboxylate;(S)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CBNumber:
CB9233339
Summenformel:
C10H20N2O3
Molgewicht:
216.28
MOL-Datei:
Mol file

(S)-1-Boc-2-(Hydroxymethyl)piperazine Eigenschaften

Siedepunkt:
324℃
Dichte
1.085
Flammpunkt:
150℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
14.97±0.10(Predicted)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2933599590
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

(S)-1-Boc-2-(Hydroxymethyl)piperazine Chemische Eigenschaften,Einsatz,Produktion Methoden

Reaktionen

(S)-1-Boc-2-(Hydroxymethyl)piperazine reacts with 1,2-difluoro-4-nitrobenzene to synthesize tert-butyl (S)-4-(2-fluoro-4-nitrophenyl)-2-(hydroxymethyl)piperazine-1-carboxylate. This compound serves as a crucial intermediate in the preparation of the Wee-1 kinase activity inhibitor.
(S)-1-Boc-2-(Hydroxymethyl)piperazine

Synthese

To a solution of (S)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (1.5 g, 4.28 mmol) in MeOH (20 mL), 10 % Pd/C (150 mg) was added. The mixture was stirred at room temperature for 3 hours under H2. Afterwards, the solid was removed by filtration and the filtrate was concentrated to yield (S)-1-Boc-2-(Hydroxymethyl)piperazine (850 mg, 3.93 mmol, 91.82 percent) as a white solid.
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(S)-1-Boc-2-(Hydroxymethyl)piperazine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1,4-Piperazinedicarboxylic acid, 2-(hydroxymethyl)-, 1-(1,1-dimethylethyl) 4-(phenylmethyl) ester, (2S)-

Downstream Produkte

(S)-1-Boc-2-(Hydroxymethyl)piperazine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 111)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Boc Chemical Co., Ltd.
021-34975602; +8618721111801
 shangli@bocchem.com China 138 58
Hangzhou FandaChem Co.,Ltd. 		+8615858145714
 FandaChem@Gmail.com China 9215 55
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830
 figo.gao@foxmail.com China 8497 58
Accela ChemBio Inc. 		+1-858-6993322
info@accelachem.com United States 17254 58
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49374 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 factory@coreychem.com China 29811 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051
 joe@yuhengpharm.com CHINA 21142 58
SIMAGCHEM CORP 		+86-13806087780
 sale@simagchem.com China 17365 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30241 58
  • (2S)-2-(Hydroxymethyl)piperazine, N1-BOC protected
  • tert-Butyl (2S)-2-(hydroxymethyl)piperazine-1-carboxylate, (2S)-1-(tert-Butoxycarbonyl)-2-(hydroxymethyl)piperazine
  • tert-butyl (S)-2-(hydroxymethyl)piperazine-1-carboxylate
  • tert-butyl (2S)-2-(hydroxymethyl)piperazine-1-carboxylate
  • (S)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • (S)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE
  • 1-PIPERAZINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)-, 1,1-DIMETHYLETHYL ESTER, (2S)-
  • (S)-tert-butyl 2-(hydroxyMethyl)piperazin-1-carboxylate
  • (S)-tert-butyl 2-(hydroxyMethyl)piperazine-1-carboxylate
  • (S)-1-Boc-2-(hyroxyMethyl)piperazine
  • 1,1-Dimethylethyl (2S)-2-(hydroxymethyl)-1-piperazinecarboxylate
  • (2S)-2-(hydroxymethyl)-1-Piperazinecarboxylic acid tert-butyl ester
  • (S)-N1-BOC-2-Hydroxymethyl-piperazine
  • 1030377-21-9
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