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Melanotan II

Melanotan II Struktur
121062-08-6
CAS-Nr.
121062-08-6
Englisch Name:
Melanotan II
Synonyma:
MT2;Melanotan 2;MelanotanII Acetate(MT-2);MT-Ⅱ;MT-II (Melanotan II);AC-NLE-CYCLO[(BETA-D)-HFRW-(EPSILON-K)]-NH2;MTII;MTIl;Melanotan ②;Melanotan Ц
CBNumber:
CB9213757
Summenformel:
C50H69N15O9
Molgewicht:
1024.18
MOL-Datei:
121062-08-6.mol

Melanotan II Eigenschaften

Dichte
1.43
RTECS-Nr.
OL4225000
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
L?slichkeit
H2O: 5 mg/mL, soluble
Aggregatzustand
solid
pka
13.00±0.70(Predicted)
Farbe
white
Wasserl?slichkeit
Soluble to 0.70 mg/ml in water
InChIKey
JDKLPDJLXHXHNV-MFVUMRCOSA-N
CAS Datenbank
121062-08-6(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
WGK Germany  3
HS Code  3504009000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

Melanotan II Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Melanotan II acetate salt has been used to study its inhibitory effects on feeding and energy expenditure in rats. It is a lab-made chemical that is similar to a hormone found in people. Melanotan II has been shown to have melanogenesis (tanning) and aphrodisiac effects on humans.

Biochem/physiol Actions

Melanotan II is a MC3-R/MC4-R melanocortin agonist. It is a high affinity melanocortin receptor agonist (Ki values are 0.67, 6.6, 34 and 46 nM for MC1, MC4, MC3 and MC5 receptors respectively). Stimulates erectile activity, inhibits food intake and displays neuroprotective properties in vivo.

Clinical Use

Melanotan II has been a new treatment for rosacea discussed in the various rosacea support groups on the internet.
Melanotan I and Melanotan II are both analogs of the peptide hormone alpha-melanocyte stimulating hormone (a-MSH) that tend to induce skin tanning. Melanotan II has the additional effect of increasing libido.
Melanotan II is an α-MSH analog which underwent clinical trials for the treatment of erectile dysfunction. Preliminary double-blind, placebo-controlled studies demonstrated the efficacy of melanotan in inducing penile erection in men with erectile dysfunction, although in a very restricted population.Unfortunately, there are no experimental data on the mode of action of melanotan II, as melanotan II is the first α-MSH agonist inducing penile erection when injected peripherally.
Illustration of the proerectile effect of melanotan II (MT-II) in humans. Placebo (A) or MT-II (B, 25 ug/kg and C, 133 ug/kg) was injected subcutaneously in patients and RigiScan recording was performed from 6 h. Apparent erections developed in 8 of 10 men treated with MT-II. (Reproduced with permission from Wessells H et al. Effect of an alphamelanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology 2000; 56:641–646.)

Nebenwirkungen

When given as a shot: Melanotan is POSSIBLY UNSAFE when given as a shot. It can causes nausea, stomachcramps, decreased appetite, flushing, tiredness, yawning, darkened skin, spontaneous erections of the penis, and other side effects. In some people, especially those with light skin, a change in the shape of moles, new moles, and skin cancer, have all occurred in people using melanotan.

Einzelnachweise

[1] SOPHIA HATZIIEREMIA. A liquid chromatographic/tandem mass spectroscopic method for quantification of the cyclic peptide melanotan-II. Plasma and brain tissue concentrations following administration in mice[J]. Rapid Communications in Mass Spectrometry, 2007. DOI:10.1002/rcm.3106.
[2] WEKWEJTPATRYK   KirykAnna  WojdaUrszula. Melanotan-II reverses memory impairment induced by a short-term HF diet.[J]. Biomedicine & Pharmacotherapy, 2023. DOI:10.1016/j.biopha.2023.115129.
[3] HJULER K F, LORENTZEN H F. Melanoma Associated with the Use of Melanotan-II[J]. Dermatology, 2013, 228: 34-36. DOI:10.1159/000356389.
[4] DORR R T, LINES R, LEVINE N, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.[J]. Life sciences, 1996, 58 20: 1777-1784. DOI:10.1016/0024-3205(96)00160-9.

Melanotan II Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Melanotan II Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 398)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weimiao Import and Export Trade Co., Ltd.
+86-19948166995 +86-19948166995
sale01@hbweimiao.com China 73 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
Shanghai Longyu Biotechnology Co., Ltd.
+8619521488211
info@longyupharma.com China 2524 58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.
+8615995072465
sales@xuanmingchem.com China 914 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58
ZhenYiBio Technology Inc
+8615309206328
alexxue@zhenyibio.com China 296 58
Wuhan Cell Pharmaceutical Co., Ltd
+86-13129979210 +86-13129979210
sales@cellwh.com China 376 58
Zhuzhou New Peptides Tech Co.,Ltd.
+86-18073326374 +86-18073326374
sales@goodpeptides.com China 56 58
Sigma Audley
+86-15937194204 +86-18126314766
nova@sh-teruiop.com China 493 58
Shaanxi Xianhe Biotech Co., Ltd
+8617709210191
Jerry@xhobio.com China 484 58

121062-08-6()Verwandte Suche:


  • Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-α-MSH (4-10) aMide Melanotan II, MTII, BreMelanotide aMide
  • AC-NLE-CYCLO(-BETA-ASP-HIS-D-PHE-ARG-TRP-EPSILON-LYS-NH2)
  • AC-NLE-CYCLO(-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2) ACETATE SALT
  • AC-NLE4-C[ASP5, D-PHE7, LYS10]ALPHA-MSH (4-10)-NH2
  • AC-[NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MSH (4-10)-NH2
  • (AC-NLE4, ASP5, DPHE7, LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE
  • AC-NLE-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2
  • (1S,4S,7S,10R,13S,16S)-16-[[(2S)-2-acetamidohexanoyl]amino]-10-(benzyl)-7-(3-guanidinopropyl)-13-(1H-imidazol-5-ylmethyl)-4-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaketo-2,5,8,11,14,19-hexazacyclotricosane-1-carboxamide
  • (1S,4S,7S,10R,13S,16S)-16-[[(2S)-2-acetamidohexanoyl]amino]-7-[3-(diaminomethylideneamino)propyl]-13-(1H-imidazol-5-ylmethyl)-4-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaoxo-10-(phenylmethyl)-2,5,8,11,14,19-hexazacyclotricosane-1-carboxamide
  • (1S,4S,7S,10R,13S,16S)-16-[[(2S)-2-acetamidohexanoyl]amino]-7-[3-[bis(azanyl)methylideneamino]propyl]-13-(1H-imidazol-5-ylmethyl)-4-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaoxo-10-(phenylmethyl)-2,5,8,11,14,19-hexazacyclotricosane-1-carboxamide
  • Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2 (AMide bond Asp5-Lys10)
  • Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-a-MSH (4-10) aMide
  • Melanotan II, MTII, BreMelanotide aMide
  • Melanotan ②
  • Malanotan II Acetate
  • Melanotan II SynonyMs Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2
  • melanotan,Melanotan II
  • Anti-MTNR1B (C-terminal) antibody produced in goat
  • melatonin receptor 1B
  • melatonin receptor MEL1B
  • Anti-MTNR1B (AB2) antibody produced in rabbit
  • Anti-MTNR1B (AB1) antibody produced in rabbit
  • mt2 melatonin receptor
  • mt2 receptor
  • Acetyl-(Nle4,Asp5,D-Phe7,Lys10)-cyclo-α-MSH (4-10) amide, Melanotan II
  • [N-ACETYL-NLE4,ASP5,D-PHE7,LYS10]-ALPHA-MSH (4-10) AMIDE ASP5-LYS10, CYCLIC LACTAM
  • MTII
  • Ac-[Nle4Asp5D-Phe7Lys10]α-MSH-(4-10)-NH2
  • Melanotan Ц
  • MalanotanIi
  • Mt-Ii(Melanotan)
  • MelanotanAcetate
  • Melanotan-II(MT-II)
  • Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-NH2
  • N-Acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide (2->7)-lactam
  • Melanotan Ⅱ Actate
  • MelanotanⅡAcetate
  • (Ac-Nle4,Asp5,D-Phe7,Lys10)-cyclo-a-MSH (4-10) amide
  • Ac-[Nle4Asp5D-Phe7Lys10]α-MSH-(4-10)-NH2
  • Melanotan II acetate salt
  • Muscarinic Toxin-2 from Dendroaspis angusticeps venom
  • Ac-Nle4, Asp5, DPhe7, Lys10-Cyclo-a-MSH: 4-10 amide, MTII
  • Melanotan-II Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys-NH2)
  • AC-NLE-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2, ASP5-LYS10, CYCLIC LACTAM
  • AC-NLE-C[+ASP-HIS-DPHE-ARG-TRP-LYS]-NH2
  • [ACETYL-NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MELANOCYTE STIMULATING HORMONE (4-10) AMIDE
  • [ACETYL-NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MSH (4-10) AMIDE
  • (ACETYL-NLE4,ASP5,D-PHE7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE ACETATE SALT
  • MELANOTAN II
  • M.W. 1024.19 C50H69N15O9
  • Melanotan II Acetate(MT-II)
  • MT2/Melanotan-II
  • Melanotan II acetate salt, ≥95% (HPLC)
  • EGF Serum Epidermal Growth Factor AFGF Powder
  • warehouse MT2
  • Melanotan II (MT-II) Acetate
  • L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, (2→7)-lactam
  • Melanotan-II/MT2
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