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QUISQUALIC ACID

QUISQUALIC ACID Struktur
52809-07-1
CAS-Nr.
52809-07-1
Englisch Name:
QUISQUALIC ACID
Synonyma:
QUISQUALATE;QUISQUALIC ACID;L-QUISQUALIC ACID;(+)-QuisqualicAci;Quisqualinic acid;()-QUISQUALIC ACID;(+)-QUISQUALIC ACID;L(+)-QUISQUALIC ACID;Quisqualic acid (7CI);QUISQUALIC ACID USP/EP/BP
CBNumber:
CB9198500
Summenformel:
C5H7N3O5
Molgewicht:
189.13
MOL-Datei:
52809-07-1.mol

QUISQUALIC ACID Eigenschaften

Schmelzpunkt:
185-187°C dec.
alpha 
D20 +17.0° (c = 2.0 in 6M HCl)
Siedepunkt:
324.36°C (rough estimate)
Dichte
1.6649 (rough estimate)
Brechungsindex
1.6190 (estimate)
storage temp. 
2-8°C
L?slichkeit
NH4OH 1 M: 20 mg/mL, clear, colorless
pka
2.12±0.10(Predicted)
Aggregatzustand
powder
Farbe
white to off-white
Wasserl?slichkeit
Soluble in ethanol, water. Insoluble in organic solvents.
Merck 
13,8177
BRN 
1078734
Stabilit?t:
Stable. Incompatible with strong oxidizing agents.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 20/21/22
S-S?tze: 26-36
WGK Germany  3
10
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H312 Gesundheitssch?dlich bei Hautkontakt. Akute Toxizit?t dermal Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P280,P302+P352, P312, P322, P363,P501
H332 Gesundheitssch?dlich bei Einatmen. Akute Toxizit?t inhalativ Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P271, P304+P340, P312
Sicherheit
P261 Einatmen von Staub vermeiden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P321 Besondere Behandlung

QUISQUALIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

L-Quisqualic acid is a natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC50s = 170, 10, 40, and 29 nM at GluR-A, mGluR1, mGluR3, and mGluR5, respectively), as well as the ionotropic kainate receptor (GRIK4; Ki = 6.43 nM). L-Quisqualic acid is used to study receptor dynamics and as an excitotoxin to selectively destroy neurons in the brain or spinal cord.

Chemische Eigenschaften

Off-White Solid

Verwenden

Quisqualic acid is used to differentiate between mGluR-1 and mGluR-4. L-Quisqualic acid is an activator of GluR.

Allgemeine Beschreibung

Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.

Biologische Aktivit?t

Glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect). Also available as part of the Group I mGlu Receptor Tocriset™ .

l?uterung methode

It has been purified by ion-exchange chromatography on Dowex 50W (x 8, H+ form); the desired fractions are lyophilised and recrystallised from H2O/EtOH. It has IR (KBr) : 3400-2750br, 1830s, 1775s, 1745s and 1605s cm-1;maxand 1H NMR (NaOD/D2O, pH 13) : 3.55-3.57 (1H m, X of ABX, H-2), 3.72-3.85 (2H, AB of ABX, H-3), 1 3C NMR (D2O) : 50.1t, 53.4d, 154.8s, 159.7s and 171.3s. [Baldwin et al. J Chem Soc, Chem Commun 256 1985.] It is a quasiqualate receptor agonist [Joels et al. Proc Natl Acad Sci USA 86 3404 1989].

QUISQUALIC ACID Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


QUISQUALIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 137)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
Shanghai UCHEM Inc.
+862156762820 +86-13564624040
sales@myuchem.com China 7514 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22883 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439
sales@nextpeptide.com China 19908 58
Labnetwork lnc.
+86-27-50766799 +8618062016861
contact@labnetwork.com China 19987 58
Henan Aochuang Chemical Co.,Ltd.
+86-0371-63689365 +8618638391208
sales@aochuangchem.com China 9237 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8467 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501
product@acmec-e.com China 33338 58

52809-07-1()Verwandte Suche:


  • 3-(3,5-DIOXO-1,2,4-OXADIAZOLIDIN-2-YL)-L-ALANINE
  • L(+)-QUISQUALIC ACID
  • L-QUISQUALIC ACID
  • L-(+)-A-AMINO-3,5-DIOXO-1,2,4-OXADIAZOLIDINE-2-PROPANOIC ACID
  • (L)-(+)-ALPHA-AMINO-3,5-DIOXO-1,2,4-OXADIAZOLIDINE-2-PROPANOIC ACID
  • BETA-[3,5-DIOXO-1,2,4-OXADIAZOLIDIN-2-YL]-L-ALANINE
  • BETA-(3,5-DIOXO-1,2,4-OXADIZOLIDIN-2-YL)-L-ALANINE
  • (+)-QUISQUALIC ACID
  • QUISQUALIC ACID
  • L-(+)-a-Amino-3,5-Dioxo-1,2,4-oxadiazolidine-2-pro
  • β-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)-l-alanine
  • QUISQUALATE
  • L-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic Acid
  • β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine
  • (S)-2-Amino-3-(3,5-dioxotetrahydro-1,2,4-oxadiazole-2-yl)propionic acid
  • (αS)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
  • (αS)-α-Amino-3,5-dioxotetrahydro-1,2,4-oxadiazole-2-propionic acid
  • Quisqualic acid,β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine
  • (S)-2-aMino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
  • 1,2,4-Oxadiazolidine-2-propanoicacid, a-aMino-3,5-dioxo-, (aS)-
  • ()-QUISQUALIC ACID
  • 1,2,4-Oxadiazolidine-2-propanoic acid, α-amino-3,5-dioxo-, (αS)-
  • (+)-QuisqualicAci
  • QUISQUALIC ACID USP/EP/BP
  • Quisqualinic acid
  • Quisqualic acid (7CI)
  • 52809-07-1
  • C5H7N3O5
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Modified Amino Acids
  • Ligand-Gated Ion Channels
  • I - Z
  • Ionotropic Glutamate Receptor Modulators
  • Ion Channels
  • Heterocycles
  • Glutamate
  • Amino Acids 13C, 2H, 15N
  • Amino Acids & Derivatives
  • Neurochemicals
  • Glutamate receptor
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