SAG
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- CAS-Nr.
- 912545-86-9
- Englisch Name:
- SAG
- Synonyma:
- SAG;SAG.HCI;CS-1655;SAG free base;SAG (Standard);SAG (Smo agonist);Smoothened Agonist;SAG.HCl(free base);SAG(Smoothened Agonist);Smoothened Agonist (SAG)
- CBNumber:
- CB91565561
- Summenformel:
- C28H28ClN3OS
- Molgewicht:
- 490.06
- MOL-Datei:
- 912545-86-9.mol
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SAG Eigenschaften
- Siedepunkt:
- 688.6±55.0 °C(Predicted)
- Dichte
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- Soluble in DMSO (up to 20 mg/ml), in DMF (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
- pka
- 10?+-.0.40(Predicted)
- Aggregatzustand
- lyophilized solid
- Farbe
- white to beige
- Sensitive
- Light Sensitive
- Stabilit?t:
- Light Sensitive
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| RIDADR |
UN 2811 6.1 / PGIII |
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| HS Code |
2934999090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
| H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
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SAG Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Orange to Red Oil
Verwenden
Smoothened agonist (SAG) dihydrochloride has been used as a sonic hedgehog (SHH) pathway agonist:
- to study its effects on mouse hippocampal cells
- to determine its effects on the mitochondrial network in zebrafish embryo
- to study its effects on murine embryonic fibroblasts
Biochem/physiol Actions
SAG is a potent and cell-permeable smoothened (Smo) agonist that activates Hedgehog pathway and counteracts Cyclopamine inhibition of Smo.
SAG Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SAG Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 116)Lieferanten
- 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]- benzo[b]thiophene-2-carboxamide
- SAG
- 3-Chloro-N-[trans-4-(MethylaMino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]Methyl]-
- SAG (cyclopamine antagonist)
- SAG (Smo agonist)
- 3-chloro-N-((1r,4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide
- Smoothened Agonist (SAG) HCl
- SAG.HCI
- SAG(Smoothened Agonist)
- Smoothened Agonist (SAG)
- Smoothened Agonist (SAG) free base
- CS-1655
- 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide
- Smoothened Agonist
- SAG free base
- SAG; SAG FREE BASE; SAG (SMO AGONIST); SAG (CYCLOPAMINE ANTAGONIST);
- Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-
- SAG (Smo agonist) free base
- SAG.HCl(free base)
- 3-Chloro-N-(trans-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide
- (2R,3S,5R)-2-((((S)-(((2R,3S,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl)oxy)(2-cyanoethoxy)phosphorothioyl)oxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SAG (Standard)
- SAG (Smo agonist), Smoothened agonist
- SAG hydrochloride, Smo activator
- 912545-86-9
- 5054-47-5
- C28H28ClN3OS
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Heterocyclic Compounds
- Heterocycles
