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Pazopanib

Pazopanib Struktur
444731-52-6
CAS-Nr.
444731-52-6
Englisch Name:
Pazopanib
Synonyma:
Votrient;5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)MethylaMino]-2-pyriMidinyl]aMino]-2-Methyl-benzenesulfonaMide;CS-1857;Pazopanib;Pazopanil;Pazopanibr;Pezopanil Hcl;Pazopanib base;Pazopanib, >=99%
CBNumber:
CB91562449
Summenformel:
C21H23N7O2S
Molgewicht:
437.52
MOL-Datei:
444731-52-6.mol

Pazopanib Eigenschaften

Schmelzpunkt:
285-289°C (dec.)
Siedepunkt:
728.8±70.0 °C(Predicted)
Dichte
1.40
Flammpunkt:
359℃
storage temp. 
Refrigerator
L?slichkeit
Aqueous Acid (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka
10.19±0.60(Predicted)
Aggregatzustand
Yellow powder.
Farbe
White to Beige
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
R-S?tze: 43-62/63
S-S?tze: 36/37/39-28B
HS Code  29350090
Giftige Stoffe Daten 444731-52-6(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H373 Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
H411 Giftig für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 2
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P391 Verschüttete Mengen aufnehmen.

Pazopanib Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Pazopanib is a multi-kinase inhibitor that inhibits the VEGF receptors VEGFR1, VEGFR2, and VEGFR3 (IC50s = 10, 30, and 47 nM, respectively, in a cell-free enzyme assay). It also inhibits PDGFRα, PDGFRβ, and c-Kit (IC50s = 71, 84, and 74 nM, respectively, in a cell-free enzyme assay) as well as additional receptor tyrosine kinases. Pazopanib inhibits upregulation of the surface adhesion proteins ICAM-1 and VCAM-1 induced by VEGF in multiple myeloma cells cocultured with human umbilical vein endothelial cells (HUVECs) and decreases multiple myeloma cell adhesion to HUVECs. It also inhibits proliferation of multiple myeloma cells cocultured with HUVECs. Pazopanib (30 and 100 mg/kg) reduces tumor growth, induces apoptosis, decreases angiogenesis, and increases survival in a multiple myeloma mouse xenograft model. Formulations containing pazopanib have been used in the treatment of cancer.

Chemische Eigenschaften

Off-White Solid

Charakteristisch

Class: receptor tyrosine kinase
Treatment: RCC, STS
Oral bioavailability = 14–39%
Elimination half-life = 31 h
Protein binding > 99.9%

Verwenden

Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.

Definition

ChEBI: A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.

Pazopanib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pazopanib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 423)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Yangzhou Qinyuan Pharmatech Co.,ltd
+86-18752526868
jennysun@yzqyyykj.com China 81 58
Shandong Risen-Sun Pharmaceutical Co., Ltd
+86-15552509998 +86-15621883869
liutf@jewim.com.cn China 251 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
shandong perfect biotechnology co.ltd
+86-53169958659 +86-13153181156
sales@sdperfect.com China 294 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152
Mandy@hangyubiotech.com China 10986 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20283 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Hi-Tech Chemistry Corp
0519-86626038
yuhh@hitechem.com CHINA 810 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55

444731-52-6()Verwandte Suche:


  • Pazopanib for research
  • Pazopanib
  • Pazopanib(GW786034)
  • 5-(4-((2,3-diMethyl-3,3a-dihydro-2H-indazol-6-yl)(Methyl)aMino)pyriMidin-2-ylaMino)-2-MethylbenzenesulfonaMide
  • 5-[(4-{[(2,3-diMethyl-2H-indazol-6-yl)Methyl]aMino}pyriMidin-2-yl)aMino]-2-Methylbenzene-1-sulfonaMide
  • 5-({4-[(2,3-diMethyl-2H-indazol-6-yl)(Methyl)aMino]pyriMidin-2-yl}aMino)-2-MethylbenzenesulfonaMide 5-(4-(N-(2,3-diMethyl-2H-indazole-6-yl)- N-MethylaMino)pyriMidine-2-ylaMino)-2-MethylbenzenesulfonaMide
  • GW786034; VOTRIENT
  • BenzenesulfonaMide, 5-[[4-[(2,3-diMethyl-2H-indazol-6-yl)MethylaMino]-2-pyriMidinyl]aMino]-2-Methyl-
  • Pazopanib base
  • Votrient(pazopanib)
  • 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide Pazopanib
  • Pazopanib 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide
  • Pazopanib, >=99%
  • 5-[4-[(2,3-Dimethyl-2H-indazol-6-yl)-methyl-amino]-pyrimidin-2-ylamino]-2-methyl-benzenesulfon
  • CS-1857
  • Pazopanib (free base) (GW786034, Votrient)
  • Pazopanib USP/EP/BP
  • Pazopanibr
  • 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide
  • PazopanibQ: What is Pazopanib Q: What is the CAS Number of Pazopanib Q: What is the storage condition of Pazopanib Q: What are the applications of Pazopanib
  • 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide
  • Votrient
  • 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)MethylaMino]-2-pyriMidinyl]aMino]-2-Methyl-benzenesulfonaMide
  • Palmer azole panitan
  • Pezopanil Hcl
  • Pazopanil
  • 444731-52-6
  • C21H23N7O2S
  • Inhibitors
  • HFC80010
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API
  • API
  • 444731-52-6
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