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ofatumumab

ofatumumab Struktur
679818-59-8
CAS-Nr.
679818-59-8
Englisch Name:
ofatumumab
Synonyma:
ofatumumab;Ofatumumab (anti-CD20);Research Grade Ofatumumab(DHC90701)
CBNumber:
CB91508605
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

ofatumumab Eigenschaften

Aggregatzustand
Liquid
Farbe
Colorless to light yellow

Sicherheit

Giftige Stoffe Daten 679818-59-8(Hazardous Substances Data)

ofatumumab Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Considered as the most common form of leukemia in adults, CLL is characterized by the accumulation of abnormal B lymphocytes and manifests itself as lymph node enlargement and bone marrow failure in symptomatic patients. Ofatumumab is the second marketed mAb to target CD20. Compared to its predecessor,it is a fully human mAb that was generated via transgenic mouse and hybridoma technology. In addition to the Fab portion that recognizes CD20, the Fc domain mediates immune effector functions to lyse cells via complement-dependent cytotoxicity (CDC) and antibody-dependent, cell-mediated cytotoxicity (ADCC). Ofatumumab targets a different, discontinuous epitope on CD20 than rituximab; it binds specifically to both the small and large extracellular loops of the CD20 molecule expressed on normal B lymphocytes and on B-cell CL, and its binding does not induce receptor internalization nor shedding from the cell surface. In addition to targeting a different epitope on CD20, ofatumumab also exhibits a slower off-rate. These characteristics have been proposed as reasons for its ability to lyse rituximab-resistant cells that express low levels of CD20 and for its greater in vitro activity against CLL cells versus rituximab.
The most common adverse events were neutropenia, pneumonia, pyrexia, cough, diarrhea, anemia, fatigue, dyspnea, rash, nausea, bronchitis, and upper respiratory tract infections.

Originator

Genmab (Denmark)

Trademarks

Arzerra

ofatumumab Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ofatumumab Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 29)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32079 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38469 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8467 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2123 70
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652
meilunui@163.com China 4727 58
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
China 1493 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9806 58
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994
2853530910@QQ.com China 8010 62
Guangzhou Hongyuan Chemical Co.,Ltd 15817493340
981810490@qq.com China 1566 58

679818-59-8()Verwandte Suche:


  • ofatumumab
  • Research Grade Ofatumumab(DHC90701)
  • Ofatumumab (anti-CD20)
  • 679818-59-8
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