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illudin S

illudin S Struktur
1149-99-1
CAS-Nr.
1149-99-1
Englisch Name:
illudin S
Synonyma:
CS-1385;Illudin;Lampterol;Illusin S;Lunamycin;illudin S;NSC 400979;Illudine S;NSC-626369;(1R,2S,5R)-1,5-dihydroxy-2-(hydroxymethyl)-2,5,7-trimethylspiro[1H-indene-6,1'-cyclopropane]-4-one
CBNumber:
CB91318110
Summenformel:
C15H20O4
Molgewicht:
264.32
MOL-Datei:
1149-99-1.mol

illudin S Eigenschaften

Schmelzpunkt:
124-126℃
Siedepunkt:
327.55°C (rough estimate)
Dichte
1.0583 (rough estimate)
Brechungsindex
1.4300 (estimate)
storage temp. 
-20°C, Inert atmosphere
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
A light yellow solid
pka
12.50±0.70(Predicted)
Farbe
Off-white to yellow

Sicherheit

illudin S Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin , epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.

Verwenden

Illudin S is potent antitumor sesquiterpene, first isolated from the fungus, Clitocybe illudens, in 1963. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumours.

illudin S Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


illudin S Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 74)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5738 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32080 58
Zhejiang Huida Biotech Co., LTD
008613515763466 8615669048680
wendy@huidabiotech.com CHINA 87 58
Shanghai Minbiotech Co., Ltd.
+8617315815539
sales@minbiotech.com CHINA 129 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15354 58
Henan Alfa Chemical Co., Ltd
+86-18339805032; +8618339805032
alfa4@alfachem.cn China 13227 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581
sales@chemhifuture.com China 3135 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58

1149-99-1()Verwandte Suche:


  • illudin S
  • (2'S,3'R,6'R)-2',3'-Dihydro-3',6'-dihydroxy-2'-hydroxymethyl-2',4',6'-trimethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one
  • Illusin S
  • Lampterol
  • NSC-626369
  • Illudin
  • Illudine S
  • Lunamycin
  • NSC 400979
  • (1R,2S,5R)-1,5-dihydroxy-2-(hydroxymethyl)-2,5,7-trimethylspiro[1H-indene-6,1'-cyclopropane]-4-one
  • CS-1385
  • Spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethyl-, (2'S,3'R,6'R)-
  • (2'S,3'R,6'R)-3',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethyl-2',3',6',7'-tetrahydrospiro[cyclopropane-1,5'-inden]-7'-one
  • 1149-99-1
  • ADC
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