illudin S
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illudin S Eigenschaften
- Schmelzpunkt:
- 124-126℃
- Siedepunkt:
- 327.55°C (rough estimate)
- Dichte
- 1.0583 (rough estimate)
- Brechungsindex
- 1.4300 (estimate)
- storage temp.
- -20°C, Inert atmosphere
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- A light yellow solid
- pka
- 12.50±0.70(Predicted)
- Farbe
- Off-white to yellow
Sicherheit
illudin S Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin , epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.Verwenden
Illudin S is potent antitumor sesquiterpene, first isolated from the fungus, Clitocybe illudens, in 1963. Illudin S is metabolically activated to reactive intermediates that bind DNA. The DNA damage appears to differ from that of other reactive metabolites. Importantly, illudin S exhibits in vitro and in vivo potency against multi-drug resistant tumours.illudin S Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
illudin S Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 74)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3882 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 |
contact@trustwe.com | China | 5738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32080 | 58 |
Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 |
wendy@huidabiotech.com | CHINA | 87 | 58 |
Shanghai Minbiotech Co., Ltd. | +8617315815539 |
sales@minbiotech.com | CHINA | 129 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
sales@afinechem.com | China | 15354 | 58 |
Henan Alfa Chemical Co., Ltd | +86-18339805032; +8618339805032 |
alfa4@alfachem.cn | China | 13227 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 |
sales@chemhifuture.com | China | 3135 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43340 | 58 |
1149-99-1()Verwandte Suche:
Lup-20(29)-en-3-ol, (3β)-
(3β,4α,16α)-3,16-Dihydroxy-23-oxoolean-12-en-28-sure
Demeton-S (ISO)
(2E,6E)-Nona-2,6-dien-1-al
3,5,5-Trimethylcyclohex-3-en-1-on
3-Methylcyclohex-3-en-1-on
2,2,4,6,6-Pentamethylhept-3-en
- illudin S
- (2'S,3'R,6'R)-2',3'-Dihydro-3',6'-dihydroxy-2'-hydroxymethyl-2',4',6'-trimethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one
- Illusin S
- Lampterol
- NSC-626369
- Illudin
- Illudine S
- Lunamycin
- NSC 400979
- (1R,2S,5R)-1,5-dihydroxy-2-(hydroxymethyl)-2,5,7-trimethylspiro[1H-indene-6,1'-cyclopropane]-4-one
- CS-1385
- Spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethyl-, (2'S,3'R,6'R)-
- (2'S,3'R,6'R)-3',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethyl-2',3',6',7'-tetrahydrospiro[cyclopropane-1,5'-inden]-7'-one
- 1149-99-1
- ADC