CV-6209 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC
50 values of 75 and 170 nM, respectively. It has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen. CV-6209 is bioavailable, as it prevents PAF-induced hypotension in rats, while not blocking hypotension triggered by arachidonic acid , histamine, bradykinin , or isoproterenol . CV-6209 is used to study the role of PAF receptor signaling
in vitro and
in vivo.
Chemische Eigenschaften
Pale-Yelow Solid
Verwenden
Competitive PAF receptor antagonist. Inhibits PAF induced human platelet aggregation. Inhibits PAF induced hypotension and lethality.
CV-6209 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte