Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)
|
|
|
- CAS-Nr.
- 365996-30-1
- Englisch Name:
- Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)
- Synonyma:
- RB4005;N-Boc-1(S),2(R)-diaMinocyclohexane;(1S,2R)-2-(Boc-amino)cyclohexylamine;(1S,2R)-N1-Boc-1,2-cyclohexanediamine;(1S,2R)-cis-N-Boc-1,2-cyclohexanediamine;(1S,2R)-2-Amino-1-(Boc-amino)cyclohexane;(1S,2R)-BOC-1,2-Diaminocyclohexane (cis);Cis-(1S, 2R)-1N-Boc-cyclohexane-1,2-diamine;tert-butyl (1S,2R)-2-aminocyclohexylcarbamate;(1S,2R)-1,2-Diaminocyclohexane, N1-BOC protected
- CBNumber:
- CB91071394
- Summenformel:
- C11H22N2O2
- Molgewicht:
- 214.3
- MOL-Datei:
- 365996-30-1.mol
|
Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI) Eigenschaften
- Siedepunkt:
- 322.1±31.0 °C(Predicted)
- Dichte
- 1.02
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Aggregatzustand
- powder to lump to clear liquid
- pka
- 12.26±0.40(Predicted)
- Farbe
- White or Colorless to Almost white or Almost colorless
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
|
|
| R-S?tze: |
38-41 |
|
|
| S-S?tze: |
26-39 |
|
|
| WGK Germany |
3 |
|
|
| HazardClass |
IRRITANT |
|
|
| HS Code |
2922498590 |
|
|
| Bildanzeige (GHS) |
 
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H318 |
Verursacht schwere Augensch?den. |
Schwere Augensch?digung |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P280, P305+P351+P338, P310 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI) Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
Triphenylphosphine (14.3 g) was added to a THF (190 ml) solution containing tert-butyl S,2S)-2-hydroxycyclohexyl) carbamate (10.0 g), followed by ice cooling. Diethyl azodicarboxylate (40% in toluene) (24.3 g) and DPPA (15.3 g) were added dropwise to the reaction solution, followed by stirring at room temperature for 1 hour. The reaction solution was left overnight. The solvent was distilled away under reduced pressure. Water was added, and then a 20% sodium hydroxide aqueous solution was added. Then, the organic layers were collected. Water (30 ml) was added to the obtained organic layers, followed by heating to 60 C. A THF (40 ml) solution containing triphenylphosphine (14.3 g) was added dropwise, followed by reflux for 2.5 hours. The solvent was distilled away under ordinary pressure. Toluene was added, and the pH was adjusted with 3M hydrochloric acid to pH=1 or less. Then, the resulting aqueous layers were collected, ethyl acetate was added, and the pH was adjusted with a 20% sodium hydroxide aqueous solution to pH 12. The organic layers were collected and dried over anhydrous sodium sulfate. Light yellow oily matter of tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate (Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI))was thus obtained.
Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Carbamic acid, N-[(1S,2S)-2-[(methylsulfonyl)oxy]cyclohexyl]-, 1,1-dimethylethyl ester
(1R,2S)-2-(N-tert-butyloxycarbonylamino)-1-azidocyclohexane
Carbamic acid, [(1R,2S)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)
cis-1,2-Diaminocyclohexane
Di(tert-butyl)carbonat
Epoxycyclohexan
Downstream Produkte
Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 161)Lieferanten
365996-30-1()Verwandte Suche:
- (1S,2R)-1,2-Diaminocyclohexane, N1-BOC protected
- tert-Butyl [(1S,2R)-2-aminocyclohex-1-yl]carbamic acid tert-butyl ester
- Cis-(1S, 2R)-1N-Boc-cyclohexane-1,2-diamine
- tert-butyl (1S,2R)-2-aminocyclohexylcarbamate
- tert-Butyl N-[(1S,2R)-2-aminocyclohexyl]carbamate
- (1S,2R)-Cyclohexane-1,2-diamine, N1-BOC protected
- tert-Butyl [(1S,2R)-2-aminocyclohex-1-yl]carbamate, (1S,2R)-1,2-Diaminocyclohexane, N1-BOC protected
- (1S,2R)-N1-(tert-Butoxycarbonyl)-1,2-cyclohexanediaMine
- (1S,2R)-N1-Boc-1,2-cyclohexanediamine
(1S,2R)-2-Amino-1-(tert-butoxycarbonylamino)cyclohexane
(1S,2R)-2-Amino-1-(Boc-amino)cyclohexane
- Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)
- RB4005
- ((1S,2R)-2-Aminocyclohexyl)carbamic acid tert-butyl ester
- tert-Butyl N-((2R,1S)-2-aminocyclohexyl)carbamate
- CarbaMic acid, [(1S,2R)-2-aMinocyclohexyl]-, 1,1-diMethylethyl ester
- CarbaMic acid,N-[(1S,2R)-2-aMinocyclohexyl]-, 1,1-diMethylethyl ester
- (1S,2R)-2-(Boc-amino)cyclohexylamine
- (1S,2R)-cis-N-Boc-1,2-cyclohexanediamine
- (1S,2R)-N-tert-Butoxycarbonyl-1,2-cyclohexanediamine
- [(1S,2R)-2-Aminocyclohex-1-yl]carbamic acid tert-butyl ester
- (1S,2R)-N1-(tert-Butoxycarbonyl)-1,2-cyclohexanediamine
- N-Boc-1(S),2(R)-diaMinocyclohexane
- N-[(1S,2S)-2-aminocyclohexyl]carbamic acid tert-butyl ester
- (1S,2R)-N1-Boc-1,2-cyclohexanediamine
- (1S,2R)-N1-(tert-Butoxycarbonyl)-1,2-cyclohexanediamine >
- (1S,2R)-2-Amino-1-(tert-butoxycarbonylamino)cyclohexane
- (1S,2R)-2-Amino-1-(Boc-amino)cyclohexane
- 1,1-Dimethylethyl N-[(1S,2R)-2-aminocyclohexyl]carbamate
- (1S,2R)-BOC-1,2-Diaminocyclohexane (cis)
- 365996-30-1
- N-BOC
