Amineptin Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Amineptine is used as an atypical tricyclic antidepressant. Amineptine selectively inhibits the reuptake of dopamine and to a lesser extent norepinephrine.
Definition
ChEBI: A carbocyclic fatty acid that is 5-aminoheptanoic acid in which one of the hydrogens attached to the nitrogen is replaced by a 10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl group. A tricyclic antidepressant, it w
s never approved in the US and was withdrawn from the French market in 1999 due to concerns over abuse, dependence and severe acne.
Enzyminhibitor
This synthetic dopamine reuptake inhibitor (FW = 338.47 g/mol; CAS 57574-09-1), also known by the trade names Survector?, Maneon?, Directim?, Neolior?, Provector?, and Viaspera? as well as its IUPAC name, 7-[(10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)amino]heptanoic acid, significantly reduces the effect of 6-hydroxy-dopamine on brain dopamine, increases striatal homovanillic acid concentrations, and shows cross-tolerance. Despite these amphetamine-like properties, amineptine does not alter brain noradrenaline or acetylcholine concentrations, suggesting amineptine is a new type of antidepressant with a brain biochemical profile differing from that of other drugs used in depressive disorders. Amineptine is also a norepinephrine reuptake inhibitor. This agent is also ineffective in reducing amphetamine withdrawal symptoms or craving. Amineptine failed to secure FDA approval and is not a duly authorized drug in the U.S.
Amineptin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
