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6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE

6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE Struktur
866405-64-3
CAS-Nr.
866405-64-3
Englisch Name:
6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE
Synonyma:
Dorsomorphin;COMPOUND C;BML-275;DORSOMORPHIN 2HCL;BML-275HCL;Dorsomorphin dihydrochloride;CS-1075;AMPK INHIBITOR;Dorsomorphin, 98%+;dorsoMorphin (BML-275)
CBNumber:
CB8786803
Summenformel:
C24H25N5O
Molgewicht:
399.49
MOL-Datei:
866405-64-3.mol

6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE Eigenschaften

Schmelzpunkt:
>228°C(dec.)
Dichte
1.25±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: >2mg/mL (warmed)
pka
8.53±0.10(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 20/21/22
S-S?tze: 36/37
WGK Germany  3
HS Code  2933599590
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Verwenden

A potent inhibitor of AMPK and fatty acid biosynthesis.

Definition

ChEBI: A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competiti e inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.

Allgemeine Beschreibung

A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 μM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 μM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo.

Biologische Aktivit?t

Potent and selective inhibitor of AMP-activated protein kinase (AMPK) (K i = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKC θ , PKA and JAK3. Inhibits AMPK activation induced by AICAR and metformin. Also inhibits bone morphogenic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro .

6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 193)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
 sales@capot.com China 29793 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
Shanghai Zheyan Biotech Co., Ltd. 		18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29880 58
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 965 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49374 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289
 contact@trustwe.com China 5738 58

866405-64-3()Verwandte Suche:

  • AMPK INHIBITOR
  • 6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE
  • AMPK Inhibitor, Compound C, Dorsomorphin
  • 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidinedihydrochloride
  • Pyrazolo[1,5-a]pyriMidine, 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-
  • DorsoMorphin, Free Base, >99%
  • 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrrazolo[1,5-a]pyrimidine
  • 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine
  • InSolution? AMPK Inhibitor, Compound C
  • AMPK Inhibitor, Compound C
  • InSolution? AMPK Inhibitor, Compound C?2HCl
  • dorsoMorphin (BML-275)
  • DorsoMorphin (CoMpound C)
  • DORSOMORPHIN(COMPOUND C; BML-275)
  • BML-275(Dorsomorphin )
  • InSolution AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem
  • InSolution AMPK Inhibitor, Compound C2HCl - CAS 866405-64-3 - Calbiochem
  • AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem
  • CS-1075
  • 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(yridine-4-yl)pyrazolo[1,5-a]pyrimidine
  • Dorsomorphin (Compound C) (DMSO solution)
  • Dorsomorphin, 98%+
  • COMPOUND C
  • BML-275
  • Dorsomorphin
  • Dorsomorphin dihydrochloride
  • DORSOMORPHIN 2HCL
  • BML-275HCL
  • AMP-activated protein kinase,inhibit,ATP-competitive,Dorsomorphin,BML 275,Inhibitor,BMP,Transforming growth factor beta receptors,Autophagy,AMPK,type,receptors,BML275,TGF-β Receptor
  • Dorsomorphin (Compound C) (DMSO solution), AMP-kinase inhibitor
  • Dorsomorphin (Compound C), AMP-kinase inhibitor
  • 866405-64-3
  • C24H25N5O2HCl
  • Inhibitors
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