CARNOSOL
|
|
|
- CAS-Nr.
- 5957-80-2
- Englisch Name:
- CARNOSOL
- Synonyma:
- carnol;CARNOSOL;D-α-Alanine;Carnosol-RM;CARNOSOL(RG);CARNOSOL USP/EP/BP;Carnosol(P)(Request Quote);Carnosol, froM RoseMarinus officinalis;Carnosol, 98%, from Rosemarinus officinalis;(5b,7a)-11,12-Dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one
- CBNumber:
- CB8736565
- Summenformel:
- C20H26O4
- Molgewicht:
- 330.42
- MOL-Datei:
- 5957-80-2.mol
|
CARNOSOL Eigenschaften
- Schmelzpunkt:
- 240～242℃
- Siedepunkt:
- 524.8±50.0 °C(Predicted)
- Dichte
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- DMSO:66.0(Max Conc. mg/mL);199.74(Max Conc. mM)
- pka
- 8.91±0.40(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White
- LogP
- 2.832 (est)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
|
| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
|
CARNOSOL Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Carnosol is a phenol that has been found in rosemary (
R. officinalis) and has diverse biological activities. It decreases nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at concentrations ranging from 6 to 25 μM. Carnosol scavenges peroxyl and hydroxyl radicals and inhibits lipid peroxidation in cell-free assays. It inhibits 5-lipoxygenase (5-LO; IC
50 = 0.1 μM for the recombinant human enzyme) and the synthesis of leukotrienes in human polymorphonuclear leukocytes (PMNs; IC
50 = 7 μM).
In vivo, carnosol (200 mg/kg) reduces mammary DNA adduct formation and tumorigenesis in a rat model of DMBA-induced mammary tumorigenesis.
Chemische Eigenschaften
White powder
Verwenden
Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.
Cytotoxicity
IC
50 (μg/mL): 65 (HL-60), 58 (K562), 50(Hep G2), 48 (MCF-7), 53 (MOLT-4)(Farimani et al. 2012)
IC
50 (μg/mL): 61.46 (AGS) (Areche et al.2009)
IC
50 (μg/mL): 2 (P388) (Aoyagi et al.2006)
IC
50 (μg/mL): 1.19 (A2780), 3.30(SW1573), 8.59 (WiDr), 7.93 (T-47D),1.29 (HBL-100) (Guerrero et al. 2006).
CARNOSOL Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CARNOSOL Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 204)Lieferanten
5957-80-2()Verwandte Suche:
- 1,3,4,9,10,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE
- 1,3,4,9,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE
- 1,2,3,4,4A,9,10,10AS-OCTAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISOPROPYL-9S, 4AR (EPOXYMETHANO)PHENANTHREN-12-ONE
- CARNOSOL(RG)
- CARNOSOL
- Carnosol, froM RoseMarinus officinalis
- Carnosol, 98%, from Rosemarinus officinalis
- 2H-9,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10aS)-
- CARNOSOL USP/EP/BP
- (4aR,9S,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-2,3,4,9,10,10a-hexahydro-1H-9,4a-(epoxymethano)phenanthren-12-one
- D-α-Alanine
- carnol
- (5b,7a)-11,12-Dihydroxy-7,20-epoxyabieta-8,11,13-trien-20-one
- Carnosol(P)(Request Quote)
- Carnosol-RM
- 5957-80-2
- chemical reagent
- pharmaceutical intermediate
- Miscellaneous Natural Products
- Antioxidant
- Biochemicals Found in Plants
- Nutrition Research
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
