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Trandolapril

Trandolapril Struktur
87679-37-6
CAS-Nr.
87679-37-6
Englisch Name:
Trandolapril
Synonyma:
Mavik;Odrik;Odric;Udrik;Gopten;Preran;ru44570;Trantowa;Ccris 6594;Olivetolic
CBNumber:
CB8682356
Summenformel:
C24H34N2O5
Molgewicht:
430.54
MOL-Datei:
87679-37-6.mol

Trandolapril Eigenschaften

Schmelzpunkt:
122-123°C
Siedepunkt:
626.0±55.0 °C(Predicted)
Dichte
1.181±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: ≥20mg/mL
Aggregatzustand
white powder
pka
3.15±0.20(Predicted)
Farbe
White to Off-White
InChIKey
VXFJYXUZANRPDJ-WTNASJBWSA-N
SMILES
N1(C(=O)[C@@H](N[C@H](C(OCC)=O)CCC2=CC=CC=C2)C)[C@]2([H])[C@]([H])(CCCC2)C[C@H]1C(O)=O
CAS Datenbank
87679-37-6(CAS DataBase Reference)

Sicherheit

WGK Germany  3
RTECS-Nr. NL6015178
HS Code  2933995300
Giftige Stoffe Daten 87679-37-6(Hazardous Substances Data)

Trandolapril Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Trandolapril is a new ACE inhibitor that is rapidly hydrolyzed, mainly in the liver, to its biologically active form, trandolaprilat. Compared with all other ACE inhibitors, trandolaprilat is reported to have the highest lipophilicity and the most prolonged ACE inhibitory activity. In hypertensive patients, trandolapril at a dose of 2 mg reduces blood pressure consistently throughout the 24 hour period after intake, making it one of the best once a day antihypertensive drugs. It has also been demonstrated to inhibit aortic atherosclerosis in the hyperlipidemic rabbit.

Chemische Eigenschaften

White or almost white powder.

Verwenden

Trandolapril has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on responsiveness of human retinal endothelial cells (HRECs) to vascular endothelial growth factor (VEGF).

Allgemeine Beschreibung

Trandolapril, 1-[2-(1-ethoxycarbonyl-3-phenylpropylamino)propionyl]octahydroindole-2-carboxylicacid (Mavik), is an indole-containing ACE inhibitorthat is structurally related to most of the precedingagents discussed. Enalapril is very similar to trandolapril,with the primary difference occurring in the heterocyclicsystems. The pyrrolidine of enalapril has been replacedwith an octahydroindole system. Much like enalaprilate,trandolapril must be hydrolyzed to tranolaprilate, which isthe bioactive species.

Trandolapril Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Trandolapril Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 213)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Accendatech Co., Ltd.
+8613132578992
yunhao.liu@accendatech.com China 251 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8807 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29810 58

87679-37-6()Verwandte Suche:


  • (2s-(1(r*(r*)),2-alpha,3a-alpha,7a-beta))-)amino)-1-oxopropyl)
  • ru44570
  • (2s,3ar,7as)-1-[(2s)-2-[[(1s)-1-ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
  • Mavik, (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-Indole-2-carboxylic acid
  • (3αR.7αS)-1-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropy]-(S)-alanyl]oetahydroindole-2(S)-carboxylic acid
  • TrandolaprilC24H34N205
  • Mavik, Odrik, Gopten, RU-44570
  • 1H-Indole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, (2S,3aR,7aS)- (9CI)
  • 1H-Indole-2-carboxylic acid, 1-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, [2S-[1[R*(R*)],2a,3aa,7ab]]-
  • Gopten
  • Odrik
  • Trandolapril/(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
  • (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-Indole-2-carboxylic Acid
  • TRANDOLAPRIL
  • 1H-Indole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1- oxopropyl)-, (2S-(1(R*(R*)),2-alpha,3a-alpha,7a-beta))
  • (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propionyl]-3a,4,5,6,7,7a-hexahydro-2-indolinecarboxylic acid
  • (2S,3aR,7aS)-1-[(S)-N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]alanyl]octahydro-1H-indole-2-carboxylic acid
  • Odric
  • Trantowa
  • (2S,3Ar,7as)-1-((S)-N-((S)-1-carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester
  • 1H-Indole-2-carboxylic acid, 1-((2S)-2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-, (2S,3ar,7as)-
  • Ccris 6594
  • Trandolapril (125 mg)
  • (2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}propanoyl]-octahydro-1H-indole-2-carboxylic acid
  • Preran
  • Tarka(coMb. with verapaMil)
  • Udrik
  • (2S,3aR,7aS)-
  • 1H-Indole-2-carboxylicacid,1-[(2S)-2-[[(1S)-
  • (2S,3aR,7aS)-1-((S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)aMino)propanoyl)octahydro-1H-indole-2-carboxylic acid
  • 1H-Indole-2-carboxylicacid,1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]aMino]-1-oxopropyl]octahydro-,(2S,3aR,7aS)-
  • Trandolapril Ph. Eur.
  • Olivetolic
  • (2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
  • Trandolapril Solution, 1000ppm
  • Trandolapril Solution, 100ppm
  • Trandolapril CRS
  • Trandolapril USP/EP/BP
  • Trandolapril (RU44570)
  • Trandolapril D6
  • TrandolaprilQ: What is Trandolapril Q: What is the CAS Number of Trandolapril Q: What is the storage condition of Trandolapril Q: What are the applications of Trandolapril
  • Trandolapril (1672687)
  • Mavik
  • RU-44570,collagen,UUD model,inhibit,arterial hypertrophy,congestive heart failure,cellular fibronectin accumulation,Angiotensin-converting Enzyme (ACE),hypertension,CHF,RU 44570,spontaneously hypertensive rats,RU44570,Trandolapril,Inhibitor,UUO model,orally active,nonsulfhydryl,myocardial infarction,unilateral ureteral obstruction,Trandolaprilat
  • Trandopril
  • 87679-37-6
  • TERRAMYCIN
  • API
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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