2'-Deoxy-2'-fluorocytidine
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- CAS-Nr.
- 10212-20-1
- Englisch Name:
- 2'-Deoxy-2'-fluorocytidine
- Synonyma:
- 2'-FC;2'-FdC;RO-8013;2'-F-dC;2'-FANA-C;NSC 529432;2’-F-2’-dC;2'-FLUORO-D-CYTIDINE;2'-Fluoro-d-Cytidine;2'-F-2'-deoxyCytidine
- CBNumber:
- CB8670324
- Summenformel:
- C9H12FN3O4
- Molgewicht:
- 245.21
- MOL-Datei:
- 10212-20-1.mol
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2'-Deoxy-2'-fluorocytidine Eigenschaften
- Schmelzpunkt:
- 167 °C
- Siedepunkt:
- 500.1±60.0 °C(Predicted)
- Dichte
- 1.82±0.1 g/cm3(Predicted)
- Brechungsindex
- 80 ° (C=1, MeOH)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- L?slichkeit
- Soluble in DMSO, Methanol.
- pka
- 12.84±0.70(Predicted)
- Aggregatzustand
- Powder
- Farbe
- White to Off-white
- Wasserl?slichkeit
- Water: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C)
- InChI
- InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1
- InChIKey
- NVZFZMCNALTPBY-XVFCMESISA-N
- SMILES
- OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](F)[C@@H]1O
- CAS Datenbank
- 10212-20-1(CAS DataBase Reference)
2'-Deoxy-2'-fluorocytidine Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
2'-Deoxy-2'-fluorocytidine is a nucleoside analog. It has antiviral effects and can synergize with T705 to effectively inhibit Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2'-Deoxy-2'-fluorocytidine can also inhibit dihydrofolate reductase, thereby preventing the production of tetrahydrofolate, which is required for the synthesis of purines and pyrimidines. It has a certain inhibitory effect on poliovirus, herpes simplex virus, vesicular stomatitis virus and influenza A virus.
Chemische Eigenschaften
White Solid
Verwenden
2'-Deoxy-2'-fluorocytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Deoxy-2'-fluorocytidine has been shown to inhibit Borna Disease virus replication and s
pread.
in vitro
2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells.
2'-Deoxy-2'-fluorocytidine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2'-Deoxy-2'-fluorocytidine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 323)Lieferanten
10212-20-1()Verwandte Suche:
- 4-amino-1-[(2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
- 4-AMINO-1-((2R,3R,4R,5R)-3-FLUORO-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-1H-PYRIMIDIN-2-ONE
- 2'-FLUORO-D-CYTIDINE
- 2'-DEOXY-2'-FLUOROCYTIDINE
- 2'-FC
- 2'-FLUORO-2'-DEOXYCYTIDINE
- 2'-FdC
- 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)cytosine
- 1-(2-Fluoro-2-deoxy-β-D-arabinofuranosyl)cytosine
- RO-8013
- 2'-DEOXY-2'-FLUOROCYTIDINE(2'-FLUORO-2'- DEOXYCYTIDINE, 2'-FC)
- 2'-Deoxy-2'-fluoro-D-cytidine
- 2''-DEOXY-2''-FLUOROCYTIDINE,99+%
- 2'-Deoxy-2'-fluorocytidine Hydrate
- 2'-Deoxy-2'-fluorocytidine ,98%
- 2'-Fluoro-2'-deoxy-β-D-ribofuranosylcytosine
- FN-009 2'-Fluoro-2'-deoxy-cytidine
- Cytidine, 2'-deoxy-2'-fluoro-
- 2'-FANA-C
- NSC 529432
- 2'-Deoxy-2'-fluorocytidine
- 2'-Deoxy-2'-fluorocytidine≥ 99% (HPLC)
- Fludarabine Phosphate Impurity 18
- 2'-Fluoro-2'-deoxycytidine, >98.0%(T)
- 2'-Deoxy-2'-fluorocytidineHydrate>
- 2’-F-2’-dC
- 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one USP/EP/BP
- 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl...
- 2'-F-2'-deoxyCytidine
- Crimean-Congo hemorrhagic fever,2' Deoxy 2' fluorocytidine,Inhibitor,nucleoside analog,inhibit,Influenza Virus,2'Deoxy2'fluorocytidine,Antiviral,CCHFV
- 2'-Fluoro-2'-Deoxycytidine (FdC)
- 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
- 2'-Fluoro-2'-Deoxycytidine
- 2'-Deoxy-2"-fuorocytidine
- 2'-F-2'-deoxycytidine
- 2'-Deoxy-2'-fluorocytidine
- 2'-F-dC
- Cytidine, 2'-deoxy-2'-fluoro-
- 2'-Fluoro-d-Cytidine
- 10212-20-1
- 110212-20-1
- C9H12FN3O4xH2O
- C9H12N3O4F
- C9H12FN3O4
- Biochemistry
- Nucleosides and their analogs
- Nucleosides, Nucleotides & Related Reagents
- 10212-20-1
- Nucleosides
- Modified（deoxy）nucleoside
- Nucleosides-2'-F Nucleosides
