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Cyclandelat

CYCLANDELATE Struktur
456-59-7
CAS-Nr.
456-59-7
Bezeichnung:
Cyclandelat
Englisch Name:
CYCLANDELATE
Synonyma:
bs572;Cydel;Natil;andeL;BS 572;Capilan;Anaspat;Lejopan;Dilatan;Novodil
CBNumber:
CB8668024
Summenformel:
C17H24O3
Molgewicht:
276.37
MOL-Datei:
456-59-7.mol

Cyclandelat Eigenschaften

Schmelzpunkt:
55.0-56.5°
Siedepunkt:
bp14 192-194°
Dichte
1.0535 (rough estimate)
Brechungsindex
1.5490 (estimate)
storage temp. 
Sealed in dry,Room Temperature
Wasserl?slichkeit
Insoluble in water
L?slichkeit
Chloroform (Slightly), Methanol (Slightly, Sonicated)
Aggregatzustand
powder to crystal
pka
12.13±0.20(Predicted)
Farbe
White to Almost white
Merck 
14,2704
EPA chemische Informationen
Benzeneacetic acid, .alpha.-hydroxy-, 3,3,5-trimethylcyclohexyl ester (456-59-7)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
RTECS-Nr. OO8200000
HS Code  2918191350
Giftige Stoffe Daten 456-59-7(Hazardous Substances Data)
Toxizit?t LD50 oral in rat: 5gm/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Cyclandelat Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Almond (Amygdalus communis L) is a kind of nut from Xinjiang, China. Traditional Chinese medicine believes that almond can promote blood circulation to dispel blood stasis, lubricate bowels to relieve constipation, and relieve cough and asthma. The indications include amenorrhea, fever, wind arthralgia, malaria, blood stasis and pain, injuries, and blood stasis with constipation.

Physikalische Eigenschaften

Appearance: white or almost white amorphous powder, special smell, and bitter taste. Solubility: very soluble in ethanol or acetone and almost insoluble in water. Melting point: 50–62 °C.

History

The chemical synthesis of cyclandelate was first synthesized by Funcke et al. from Elan Corporation in Ireland using a-hydroxyphenylacetic acid and cis-3,3,5-cycloalkyl cyclohexanol. The raw material of mandelic acid was obtained by hydrolysis after benzaldehyde reacted to sodium cyanide. However, sodium cyanide is hypertoxic, and because of its unique structure of a-hydroxy acid, it is easy to decompose under the acid condition, which leads to more by-products and low yield. A series of improved methods have been developed, which can reduce the environmental pollution under the premise of ensuring the yield of Zn/HCOONH4/ C2H5OH system . The method was used to synthesize cyclandelate since then. However, this drug has not yet been approved by the Food and Drug Administration in the United States, Canada, and other countries because it easily causes white blood cell deficiency. It has been withdrawn from the market after drug approval in Japan, France, and other countries in the 1970s.

Verwenden

vasodilator

Definition

ChEBI: The ester obtained by formal condensation of mandelic acid and 3,3,5-tricyclohexanol. It is a direct-acting smooth muscle relaxant used to dilate blood vessels.

Indications

The indications of cyclandelate are arteriosclerosis obliterans, acrocyanosis, cerebral arteriosclerosis, cerebral insufficiency, cerebrovascular disease, brain trauma, and post-traumatic brain syndrome.

Weltgesundheitsorganisation (WHO)

Cyclandelate is a papaverine type spasmolytic and vasodilating drug intended for symptomatic treatment of various peripheral vascular disorders, such as intermittent claudication in arteriosclerosis obliterans as well as a treatment for cognitive dysfunction in patients suffering from senile dementia of the multi-infarct or Alzheimer's type. Cyclandelate remains registered in several countries.

Pharmakologie

The chemical structure and effect of cyclandelate are similar to papaverine. It can directly relax vascular smooth muscle and relieve the spasm of ileum and uterus smooth muscle induced by acetylcholine, histamine, and barium chloride in guinea pig. This effect is three to five times stronger than papaverine. Cyclandelate can also expand the cardiovascular, cerebrovascular, and renal blood vessels and limb peripheral vascular and coronary artery, increase blood flow, and promote blood circulation . It can also increase the tolerance to hypoxia, but the effect on human cerebral blood flow has not been confirmed. It was reported that cyclandelate can promote collateral circulation but has little effect on respiration, blood pressure, cardiac output, and myocardial oxygen consumption. It is safe for long-term administration .

Clinical Use

Cyclandelate can be used for clinical treatment of cerebral arteriosclerosis, cerebral vascular accident and its sequelae, post-traumatic brain syndrome, coronary arteriosclerosis, hypertensive heart disease, Raynaud’s disease, thromboangiitis obliterans, acrocyanosis, and Meniere’s disease .

Cyclandelat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cyclandelat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 170)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12825 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8816 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32002 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34553 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23541 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15361 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58

456-59-7(Cyclandelat)Verwandte Suche:


  • CYCLANDELATE
  • 3,5,5-trimethylcyclohexylamygdalate
  • 3,5,5-trimethylcyclohexylmandelate
  • alpha-Hydroxybenzeneacetic acid 3,3,5-trimethylcyclohexyl ester
  • alpha-hydroxybenzeneaceticacid3,3,5-trimethylcyclohexylester
  • Arto-espasmol
  • Benzeneacetic acid, alpha-hydroxy-, 3,3,5-trimethylcyclohexyl ester
  • benzeneaceticacid,alpha-hydroxy-,3,3,5-trimethylcyclohexylester
  • BS 572
  • bs572
  • Capilan
  • 3,3,5-Trimethylcyclohexanol alpha-phenyl-alpha-hydroxyacetate
  • 3,3,5-trimethylcyclohexanolalpha-phenyl-alpha-hydroxyacetate
  • Ciclospasmol
  • Clandilon
  • MANDELIC ACID 3,3,5-TRIMETHYLCYCLOHEXYL ESTER
  • 3,3,5-TRIMETHYLCYCLOHEXYL MANDELATE
  • MANDELIC ACID 3,3,5-TRIMETHYLCYCLOHEXYL ESTER 98+%
  • 3,3,5-Trimethylcyclohexanol α-phenyl-α-hydroxyacetate
  • Benzeneacetic acid, α-hydroxy-, 3,3,5-trimethylcyclohexyl ester
  • Cyclohexanol, 3,3,5-trimethyl-, mandelate (8CI)
  • Mandelic acid, 3,3,5-trimethylcyclohexyl ester (6CI, 7CI, 8CI)
  • Anaspat
  • Ancyclin
  • Cydel
  • Lejopan
  • (3,3,5-trimethylcyclohexyl) 2-hydroxy-2-phenylacetate
  • (3,3,5-trimethylcyclohexyl) 2-hydroxy-2-phenyl-ethanoate
  • 2-hydroxy-2-phenyl-acetic acid (3,3,5-trimethylcyclohexyl) ester
  • Cyclandelate (200 mg)
  • Cyclandelate, USP
  • Cyclandelate Mandelic Acid 3,3,5-Trimethylcyclohexyl Ester
  • 3,3,5-TriMethylcyclohexyl Mandelate (Mixture of isoMers)
  • 3,3,5-Trimethylcyclohexyl hydroxy(phenyl)acetate
  • 3,5,5-trimethylcyclohexanol,mandelicacidester
  • 3,5,5-Trimethylcyclohexyl amygdalate
  • Cyclandelate (mixture of isomers)
  • Cyclergine
  • Cyclobral
  • Cyclolyt
  • Cyclomandol
  • Cyclospasmol
  • Dilatan
  • Natil
  • Novodil
  • Perebral
  • Saiclate
  • Sancyclan
  • Sepyron
  • Spasmione
  • Spasmocyclon
  • Spasmocyclone
  • 5-Trimethylcyclohexyl mandelate
  • 3,3,5-TrimethylcyclohexylMandelate(mixtureofisomers)>
  • Trimethylcyclohexyl isomers
  • andeL
  • ate (mixture of isomers)
  • CYCLANDELATE USP/EP/BP
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