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SR 12813

SR 12813 Struktur
126411-39-0
CAS-Nr.
126411-39-0
Englisch Name:
SR 12813
Synonyma:
GW485801;GW 485801;GW-485801;SR12813;SR 12813;SR-12813(GW 485801);SR-12813, PXR agonist;SR-12813;SR12813;SR 12813;GW 485801;GW-485801;GW485801;GW-485801,GW485801,HMG-CoA Reductase (HMGCR),Autophagy,SR12813,inhibit,Inhibitor;Tetraethyl (2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl)bis(phosphonate);[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonicacidtetraethylester
CBNumber:
CB8497376
Summenformel:
C24H42O7P2
Molgewicht:
504.53
MOL-Datei:
126411-39-0.mol

SR 12813 Eigenschaften

Schmelzpunkt:
119-121℃
Siedepunkt:
552.6±50.0 °C(Predicted)
Dichte
1.117±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
DMSO: ≥10 mg/mL
Aggregatzustand
solid
pka
9.95±0.70(Predicted)
Farbe
White to off-white

Sicherheit

WGK Germany  3
HS Code  29319090

SR 12813 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

SR 12813 is a pregnane X receptor (PXR, NR 112) agonist.

Definition

ChEBI: An organic phosphonate that is the tetraethyl ester of [2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl]bis(phosphonic acid).

Biologische Aktivit?t

Pregnane X receptor (PXR) agonist (EC 50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μ M concentrations. Displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase.

SR 12813 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

SR 12813 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 60)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
BOC Sciences 1-631-485-4226; 16314854226
 info@bocsci.com United States 14055 65
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652
 sales@meilune.com China 4727 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
 isunpharm@qq.com China 4674 55

126411-39-0()Verwandte Suche:

  • [[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonicacidtetraethylester
  • SR-12813(GW 485801)
  • SR-12813;SR12813;SR 12813;GW 485801;GW-485801;GW485801
  • GW 485801
  • GW485801
  • GW-485801
  • SR12813;SR 12813
  • Phosphonic acid, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, P,P,P',P'-tetraethyl ester
  • GW-485801,GW485801,HMG-CoA Reductase (HMGCR),Autophagy,SR12813,inhibit,Inhibitor
  • Tetraethyl (2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethene-1,1-diyl)bis(phosphonate)
  • SR-12813, PXR agonist
  • 126411-39-0
  • C24H42O7P2
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