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O-Desmethylvenlafaxine

O-Desmethylvenlafaxine Struktur
93413-62-8
CAS-Nr.
93413-62-8
Englisch Name:
O-Desmethylvenlafaxine
Synonyma:
DVS 233;Wy-45233;desvenlafaxine;Desvenlafaxine Base;Effexor Impurity 36;Desmethylvenlafaxine;O-desMethylvenlafaxin;O-Desmethylvenlafaxine;Venlafxine-O-Desmethyl;Venlafaxine Impurity 36
CBNumber:
CB8496834
Summenformel:
C16H25NO2
Molgewicht:
263.38
MOL-Datei:
93413-62-8.mol

O-Desmethylvenlafaxine Eigenschaften

Schmelzpunkt:
208-213°C
Siedepunkt:
403.8±25.0 °C(Predicted)
Dichte
1.115±0.06 g/cm3(Predicted)
Flammpunkt:
9℃
storage temp. 
2-8°C
L?slichkeit
insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH
Aggregatzustand
Solid
pka
10.04±0.26(Predicted)
Farbe
White to off-white
InChIKey
KYYIDSXMWOZKMP-UHFFFAOYSA-N
LogP
0.33 at 25℃ and pH6
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher F,T,Xi
R-S?tze: 11-23/24/25-39/23/24/25-36
S-S?tze: 7-16-36/37-45-26
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS-Nr. GV8872620
HS Code  29225090
Giftige Stoffe Daten 93413-62-8(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

O-Desmethylvenlafaxine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC50=47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.

Chemische Eigenschaften

White Solid

Verwenden

A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant

Definition

ChEBI: A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine.

Allgemeine Beschreibung

An analytical reference standard applicable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as urine drug testing, forensic analysis, or clinical toxicology. Also known as desvenlafaxine, O-desmethylvenlafaxine is an SNRI antidepressant marketed under the trade name Pristiq? for the treatment of depression. O-desmethylvenlafaxine is also a major urinary metabolite of venlafaxine, an SNRI antidepressant sold as Effexor? or Efexor and used to treat major depressive disorder, generalized anxiety disorder, and other anxiety disorders associated with depression.

O-Desmethylvenlafaxine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


O-Desmethylvenlafaxine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 245)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
sales@fine-chemtech.com CHINA 885 55
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 295 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2930 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58

93413-62-8()Verwandte Suche:


  • O-DESMETHYL VENLAFAXINE-D10
  • DL-O-Desmethylvenlafaxin
  • 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol
  • O-Desmethylvenlafaxine
  • Desvenlafaxine(O-Desnethylvenfaxine)
  • 1-[1-(4-Hydroxyphenyl)-2-dimethylaminoethyl]cyclohexanol
  • 4-[1-(1-Hydroxycyclohexyl)-2-(dimethylamino)ethyl]phenol
  • Desmethylvenlafaxine
  • Wy-45233
  • O-desMethylvenlafaxin
  • DVS 233
  • desvenlafaxine
  • O-DesMethyl Venlafaxine Hydrochloride
  • Venlafaxine O-DesMethyl IMpurity
  • Desvenlafaxine (O-DesMethyl venlafaxine)
  • Phenol,4-[2-(diMethylaMino)-1-(1-hydroxycyclohexyl)ethyl]-
  • Desvenlafaxine Base
  • O-Desmethylvenlafaxine solution
  • O-Desmethylvenlafaxine(DL)
  • Desvenlafaxine impurity C
  • Venlafaxine-d10 HCl O-Desmethyl Venlafaxine-d10
  • O-Desmethylvenlafaxine, 98%, a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor
  • D,L-O-Desmethyl Venlafaxine (100 μg/mL in Methanol)
  • O-Desmethylvenlafaxine USP/EP/BP
  • Desvenlafaxine (WY 45233
  • Venlafaxine Impurity 36
  • DesvenlafaxineQ: What is Desvenlafaxine Q: What is the CAS Number of Desvenlafaxine Q: What is the storage condition of Desvenlafaxine Q: What are the applications of Desvenlafaxine
  • 93413-62-8 O-Desmethylvenlafaxine
  • Venlafxine-O-Desmethyl
  • Venlafaxine O-Desmethyl
  • O-Desmethyl Venlafaxine (Free base)
  • O-Desmethylvenlafaxine in methanol
  • Effexor Impurity 36
  • 93413-62-8
  • 96413-62-8
  • PRISTIQ
  • Metabolite & impurity
  • Metabolites
  • Intermediates & Fine Chemica
  • Pfizer Compounds
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
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