Leuprorelin
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- CAS-Nr.
- 53714-56-0
- Englisch Name:
- Leuprorelin
- Synonyma:
- LEUPROLIDE;Lucrin;Leuplin;a-43818;Carcinil;Enantone;nghormone;LEUPRORELIN;LEUPROPELIN;Leuprorelinum
- CBNumber:
- CB8398455
- Summenformel:
- C59H84N16O12
- Molgewicht:
- 1209.4
- MOL-Datei:
- 53714-56-0.mol
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Leuprorelin Eigenschaften
- alpha
- D25 -31.7° (c = 1 in 1% acetic acid)
- Dichte
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- pka
- 9.82±0.15(Predicted)
- Wasserl?slichkeit
- Soluble in water at 1mg/ml
- Stabilit?t:
- Hygroscopic
- InChIKey
- RGLRXNKKBLIBQS-VAZQWRJQNA-N
- CAS Datenbank
- 53714-56-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H360 |
Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Fertility (Fruchtbarkeit) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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Leuprorelin Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Hygroscopic, white or almost white powder.
Verwenden
Gonadotropin releasing hormone (gonadorelin) analogue; treatment of prostate cancer.
Definition
ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. Leuprorelin is a synthetic nonapeptide analogue of gonadotropin-releasi
g hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
Indications
Leuprolide is a potent LH-RH agonist for the first
several days to a few weeks after initiation of therapy,
and therefore, it initially stimulates testicular and ovarian
steroidogenesis. Because of this initial stimulation of
testosterone production, it is recommended that patients
with prostatic cancer be treated concurrently with
leuprolide and the antiandrogen flutamide (discussed
earlier). Leuprolide is generally well tolerated, with hot
flashes being the most common side effect.
Synthese
The synthesis process of Leuprorelin includes the following steps:
(1) Fmoc-Pro-HMPB-AM resin is obtained from Fmoc-Pro-OH and HMPB-AM resin with a substitution degree of 0.2mmol/g～1.2mmol/g as starting materials;
(2) The Fmoc-Pro-HMPB-AM resin was coupled one by one by Fmoc/tBu solid phase method to connect amino acids with protective groups in sequence, and the side chain fully protected leuprolide precursor peptide-HMPB-AM was synthesized Resin;
(3) Cut the side chain fully protected leuprolide precursor peptide-HMPB-AM resin to obtain the side chain fully protected leuprolide precursor peptide;
(4) Fully protected side chain leuprolide precursor peptide undergoes ethylamination to obtain side chain fully protected leuprolide;
(5) Leuprolide is fully protected on the side chain by removing the side chain protecting group to obtain the crude leuprolide peptide;
(6) The crude leuprorelin peptide is separated and purified by a high-pressure liquid phase column and lyophilized to obtain the leuprolide refined peptide.
Leuprorelin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Leuprorelin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 291)Lieferanten
53714-56-0()Verwandte Suche:
- Leuprorelin Acetate(Leuprolide Acetate)
- LEUPRORELIN (LEUPROLIDE) ACETATE
- Leuprorelin###Leuprorelin acetate
- 1-(2-cyclohexyl-1-methylethyl)hydrazine hydrochloride
- Leuprelin Acetate
- LH-RH LEUPROLIDE
- LEUPROLIDE (HUMAN)
- LEUPRORELIN
- [DES-GLY10, D-LEU6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE HUMAN
- (DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
- (DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
- [DES-GLY10, D-LEU6, PRO-NHET9]-LH-RH (HUMAN)
- DES-GLY10,[P-LEU6]-LH-RH ETHYLAMIDE
- (DES-GLY10,D-LEU6,PRO-NHET9)-LHRH
- (DES-GLY10,D-LEU6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
- [DES-GLY10, DLEU 6, PRONHET9]
- [DES-GLY10, DLEU6, PRO9]-LUTEINIZING HORMONE-RELEASING HORMONE, ETHYL AMIDE
- [DES-GLY10, DLEU6, PRO9]-LH-RH, ETHYL AMIDE
- GLP-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHET
- 5-OXOPRO-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHC2H5
- PGLU-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHET
- PGLU-HIS-TRP-SER-TYR-P-LEU-LEU-ARG-PRO-NHET
- PYROGLU-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO NHCH2CH3
- PYR-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHET
- 6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamideluteinizing hormone-releasing factor(pig)
- Carcinil
- Enantone
- Leuplin
- Lucrin
- (D-Leu6, des-Gly-NH210)-LH-RH ethylamide
- Des-Gly10-[D-Leu6]-LH-releasing hormone ethylamide
- N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(Diaminomethylideneamino)-1-[2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxo-pentan-2-yl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-(4-hydroxyphenyl)ethyl]carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl]-2-(3H-imidazol-4-yl)ethyl]-5-oxo-pyrrolidine-2-carboxamide
- [D-Leu6,des-Gly10]GnRH ethylamide
- 10-des-Gly-6-D-Leu-LH-RH-ethylamide
- 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-D-Leu-L-Leu-L-Arg-L-Pro-N-ethyl-NH2
- GLP-HIS-TRP-SER-TYR-DLEU-LEU-ARG-PRO-NHET: GLP-HWSY-DL-LRP-NHET
- 1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-D-LEUCINE-9-(N-ETHYL-L-PROLINAMIDE)-
- LEUPROLIDE ACETATE PH. EUR.
- Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt acetate salt
- (d-leu(sup6),des-gly-nh2(sup10),pro-ethylamide(sup9))-gnrh
- (d-leu(sup6),des-gly-nh2(sup10),pro-ethylamide(sup9))-gonadotropin-releasi
- (d-leu(sup6),des-gly-nh2(sup10),pro-ethylamide(sup9))-lhrh
- a-43818
- de)-10-deglycinamide-
- luteinizinghormone-releasinghormone(pig),6-d-leucine-9-(n-ethyl-l-prolinami
- nghormone
- 5-Oxo-L-prolil-L-histidil-L-tryptophil-L-seril-L-thyrozil-D-leucil-L-arginil-N-ethyl-L-prolinamide
- LEUPROPELIN
- Leuprolide, Leuprorelin, Leuproreline, Leuprorelinum
- Leuprorelinum
- N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)-1-pyrrolidinyl]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(4-h
- Leuprorelin mesylate
- Leuprorelin Acetate / Leuprorelin
- Leuprorelin CRS
- Leuprorelin USP/EP/BP
- Anti-cancer Leuprorelin acetate 74381-53-6
- Anti-cancer Leuprorelin acetate
- Leuprorelin (L0376000)
