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Pterostilbene

Pterostilbene Struktur
537-42-8
CAS-Nr.
537-42-8
Englisch Name:
Pterostilbene
Synonyma:
pterostibene;hydroxystilbene;AKOS 236-80;PTEROSTILBENE;(Z)-3,4’-aminostilbene;(E/Z)-3,4’POVIDONE USP(RG);Pterostilbene>PTEROSTILBENE(FG)
CBNumber:
CB8373368
Summenformel:
C16H16O3
Molgewicht:
256.3
MOL-Datei:
537-42-8.mol

Pterostilbene Eigenschaften

Schmelzpunkt:
89-92 ºC
Siedepunkt:
420.4±35.0 °C(Predicted)
Dichte
1.169±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: >20mg/mL
pka
9.96±0.26(Predicted)
Aggregatzustand
solid
Farbe
White or off-white
Geruch (Odor)
Characteristic
maximale Wellenl?nge (λmax)
321nm(MeOH)(lit.)
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
InChI
InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
InChIKey
VLEUZFDZJKSGMX-ONEGZZNKSA-N
SMILES
C1(O)=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2)C=C1
LogP
4.056 (est)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi,N
R-S?tze: 41-51/53
S-S?tze: 26-39-61
RIDADR  3077
WGK Germany  3
HazardClass  IRRITANT
PackingGroup 
HS Code  29095000
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H318 Verursacht schwere Augensch?den. Schwere Augensch?digung Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS05.jpg" width="20" height="20" /> P280, P305+P351+P338, P310
H411 Giftig für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 2
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P391 Verschüttete Mengen aufnehmen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Pterostilbene Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R41:Gefahr ernster Augensch?den.
R51/53:Giftig für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.

Beschreibung

Pterostilbene (PTS) is a fragrant-smelling hydrocarbon called "styrene", which is a derivative of resveratrol. It is found in blueberries and Pterocarpus marsupium (PM) heartwood. Similar to resveratrol, PTS has anti-inflammatory, anti-thrombotic, anti-cancer, anti-cancer, anti-hyperlipidemia and antibacterial effects.

Chemische Eigenschaften

Pterostilbene is a white crystalline powder, sensitive to air, soluble in hot methanol, DMSO, insoluble in water. It is a stilbenoid chemically similar to resveratrol and from the leguminous plant Pterocarpus indicus.

Occurrence

Pterostilbene is a natural molecule found in fruits, vegetables and nuts. Blueberries are often quoted as one of the richest sources of pterostilbene. It is also found in almonds,various Vaccinium berries (including blueberries), grape leaves and vines,and Pterocarpus marsupium heartwood.

Verwenden

Substantial studies demonstrate that pterostilbene has diverse pharmacological activities for the prevention and treatment of diseases including inflammation, cancer, diabetes, and dyslipidemia.
Pterostilbene has been used:
to investigate its anti-oxidative stress activities and the involvement of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) signaling pathway
to determine its effects on transcriptional activation of estrogen receptor-α (ERα) in hormone resistant breast cancer cells)

synthetische

Pterostilbene was synthesized from 3,5-dimethoxybenzyl bromide and p-nitrobenzaldehyde by Witting-Hornor reaction, reduction, diazotization and hydrolysis, with a total yield of 53.9%.
synthesis of Pterostilbene

Definition

ChEBI: Pterostilbene is a stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'. It has a role as an antioxidant, an antineoplastic agent, a neurotransmitter, a plant metabolite, an apoptosis inducer, a neuroprotective agent, an anti-inflammatory agent, a radical scavenger and a hypoglycemic agent. It is a stilbenol, a member of methoxybenzenes and a diether. It derives from a hydride of a trans-stilbene.

benefits

Pterostilbene is a naturally-derived stilbenoid structurally related to resveratrol, with potential antioxidant, anti-inflammatory, pro-apoptotic, antineoplastic and cytoprotective activities. Pterostilbene is known to have many pharmacological benefits for the prevention and treatment of a wide variety of diseases, including ( cancer (McCormack and McFadden 2012), dyslipidaemia (Rimando et al. 2005), diabetes (Amarnath Satheesh and Pari 2006), cardiovascular degeneration (Amarnath Satheesh and Pari 2008) and pain (Hougee et al. 2005).

Nebenwirkungen

The side effects of pterostilbene are relatively minor, but you still need to pay attention to the dosage. Low-dose pterostilbene supplementation improves cholesterol metabolism and reduces triglyceride levels. Side effects include mild weight loss and muscle pain, but dose adjustment is usually not necessary.

Pterostilbene Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pterostilbene Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 530)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953
sales@pioneerbiotech.com China 1287 58
PNP Biotech Co. Ltd
+8618516098983
sales@pnpbiotech.com China 1001 58
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907
qinhe02@xaltbio.com China 997 58
Beri Pharma Co., Ltd.
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sales@zhberi.com China 227 58
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+86-2102300 +86-18632882519
hy@haoyecom.cn China 300 58
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sales1@chuanghaibio.com China 5889 58
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537-42-8()Verwandte Suche:


  • AKOS 236-80
  • 3,5-DIMETHOXY-4'-HYDROXYSTILBENE
  • 3',5'-DIMETHOXY-4-STILBENOL
  • 4-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]PHENOL
  • PTEROSTILBENE
  • PTEROCARPUS MARSUPIUM
  • TRANS-3,5-DIMETHOXY-4'-HYDROXYSTILBENE
  • (E)-3,5-Dimethoxy-4'-hydroxystilbene
  • (E)-3',5'-Dimethoxystilbene-4-ol
  • 4-[(E)-2-(3,5-Dimethoxyphenyl)vinyl]phenol
  • 4-[(E)-3,5-Dimethoxystyryl]phenol
  • trans- Pterostilbene
  • Pterostilbene CAS 537-42-8 Phenol,4-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]- 3,5-DiMethoxy-4'-hydroxy-trans-stilbene
  • Phenol,4-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]-
  • Pterostilbene 3',5'-Dimethoxy-4-stilbenol
  • 3,5-Dimethoxy-4'-hydroxy-trans-stilbene
  • 4-(2-(3,5-Dimethoxyphenyl)
  • 4-[2-(3,5-dimethoxyphenyl)ethenyl]phenol
  • 4-[2-(3,5-dimethoxyphenyl)vinyl]phenol
  • 4-Stilbenol, 3',5'-dimethoxy-, (E)-
  • Phenol, 4-(2-(3,5-dimethoxyphenyl)ethenyl)-, (E)-
  • Pterostilbene, Pterocarpus marsupium
  • trans-3,5-Dimethoxy-4&prime
  • Pterostilbene, Pterocarpus marsupium
  • 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol, Pterocarpus marsupium
  • (E)-4-[2-(3,5-dimethoxyphenyl)ethenyl]-Phenol
  • -4-(3,5-Dimethoxystyryl)
  • phenol, 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]-
  • POVIDONE USP(RG)
  • PTEROSTILBENE(FG)
  • PTEROSTILBENE(DS)
  • 4-(3,5-DiMethoxystyryl)phenol
  • 4'-Hydroxy-3,5-dimethoxy-trans-stilbene trans-1-(3,5-Dimethoxyphenyl)-2-(4-hydroxyphenyl)ethylene
  • 4'-Hydroxy-3,5-diMethoxystilbene
  • PTEROSTILBENE(FG)(REQUEST QUOTE)
  • Pterostilbene IN STOCK
  • Pterostilbene Factory
  • Pterostilbene COA
  • Pterostilbene, Pterocarpus marsupium - CAS 537-42-8 - Calbiochem
  • NanoLiposomal Pterostilbene
  • nootropic blueberry extract Pterostilbene powder
  • (Z)-3,4&rsquo
  • 5-Trimethoxy-3&rsquo
  • Pterostilbene 99.8%
  • BioaActive Pterostilbene
  • Nanoactive Pterostilbene
  • Soluble Pterostilbene
  • (E/Z)-3,4&rsquo
  • -aminostilbene
  • -(tert-butyldimethylsilyloxy)stilbene
  • Liposomal PTEROSTILBENE, PTEROSTILBENE NanoEmulsion, NanoActive PTEROSTILBENE,Water/Oil-Soluble PTEROSTILBENE
  • Pterostilbene>
  • Pterostilbene powder
  • 4'-Hydroxy-3,5-dimethoxy-trans-stilbene
  • trans-1-(3,5-Dimethoxyphenyl)-2-(4-hydroxyphenyl)ethylene
  • nootropic blueberry extract Pterostilbene
  • Pterostilbene Powder CAS No 537-42-8 Pterostilbene 98%
  • 3,5-Dimethoxy-4-hydroxystilbene, 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol,
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