3D-O-(4-O-Acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexapyrano-syl)-7-methylolivomycin D
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3D-O-(4-O-Acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexapyrano-syl)-7-methylolivomycin D Eigenschaften
- Schmelzpunkt:
- 185℃
- alpha
- D23 -57° (ethanol)
- Siedepunkt:
- 780.13°C (rough estimate)
- Dichte
- 1.1451 (rough estimate)
- Brechungsindex
- 1.6500 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in ethanol, DMSO, and ethyl acetate (10 mg/ml).
- Aggregatzustand
- Yellow solid
- pka
- 4.54±0.60(Predicted)
- Farbe
- Yellow
- Merck
- 13,2258
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | T+,T | ||
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R-S?tze: | 61-28 | ||
S-S?tze: | 53-28-36/37/39-45 | ||
RIDADR | UN 3462 6.1/PG 1 | ||
WGK Germany | 3 | ||
RTECS-Nr. | GB7875000 | ||
F | 3-8-10 | ||
HazardClass | 6.1(a) | ||
PackingGroup | I | ||
HS Code | 29419090 | ||
Toxizit?t | Excitation max: ~445 nm. Emission max: ~575 nm. Sol in ethanol, ethyl acetate, DMSO, methanol. LD50 in mice (mg/kg): 1.85 i.v. (Slavik, Carter). |
Bildanzeige (GHS) |
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Alarmwort | Achtung | ||||||||||||||
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Sicherheit |
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3D-O-(4-O-Acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexapyrano-syl)-7-methylolivomycin D Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R61:Kann das Kind im Mutterleib sch?digen.R28:Sehr giftig beim Verschlucken.
S-S?tze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Beschreibung
Chromomycin A3 is an anthraquinone antibiotic and antitumor agent isolated from S. griseus that is used as a fluorescent probe for DNA with excitation/emission spectra of 445/575 nm. Its DNA binding is specific to two or more contiguous GC base pairs, which makes it suitable for characterizing heterochromatin in plants with species-specific AT:GC ratios. Chromomycin A3 is cytotoxic against non-small cell lung cancer and cervical cancer in vitro (IC50s = 1, 42, 60, and 40 nM for HCC44, A549, ME180, and HeLa cells, respectively). It also inhibits oxidative stress- and DNA damage-induced neuronal injury by enhancing Sp1 and Sp3 transcription factor binding.Chemische Eigenschaften
Yellow powderVerwenden
Chromomycin A3 is the major component of the chromomycin complex of the aureolic acid class, isolated from several Streptomyces species, and first reported in 1960. Chromomycin A3 exhibits a broad biological profile as an antibacterial, antifungal and antitumour agent. It binds reversibly to GC-specific DNA ligand in the minor groove which inhibits transcription, DNA gyrase and topoisomerase II activity. The intense UV spectrum and strong fluorescence makes chromomycin a useful stain for DNA.Allgemeine Beschreibung
Chemical structure: aureolic acidl?uterung methode
Dissolve the antibiotic (10g) in EtOAc and add to a column of Silica Gel (Merck 0.05-0.2microns, 4x70cm) in EtOAc containing 1% oxalic acid. Elute with EtOAc+1% oxalic acid and check fractions by TLC. Pool fractions, wash with H2O thoroughly, dry and evaporate. Recrystallise the residue from EtOAc. The heptaacetate has m 214o, [] D -20o (c 1, EtOH). [Miyamoto et al. Tetrahedron 23 421 1967, Harada et al. J Am Chem Soc 91 5896 1969, Beilstein 17/5 V 673.]3D-O-(4-O-Acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexapyrano-syl)-7-methylolivomycin D Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3D-O-(4-O-Acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexapyrano-syl)-7-methylolivomycin D Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 110)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
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admin@zlchemi.com | China | 3692 | 58 |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 |
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BOC Sciences | +1-631-485-4226 |
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TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32159 | 58 |
Longyan Tianhua Biological Technology Co., Ltd | 0086 18039857276 18039857276 |
CHINA | 2783 | 58 | |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 |
sales@tnjchem.com | China | 34563 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 22858 | 58 |
7059-24-7(3D-O-(4-O-Acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexapyrano-syl)-7-methylolivomycin D)Verwandte Suche:
1-(6-Methoxy-2-naphthyl)propan-1-on
Isovalerophenon
5-Hydroxyoctan-4-on
2,3,6-Trimethylnaphthalin
6-Methoxynaphthalin-2-carbaldehyd
2,3-Dimethylnaphthalin
Naphthalin-1,6-diol
Heptan-2,6-dion
1-(6-Methoxy-2-naphthyl)ethan-1-on
5,6,7,8-Tetrahydro-1-naphthol
Naphthalin-2-ethanol
2,7-Dimethylnaphthalin
3D-O-(4-O-Acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexapyrano-syl)-7-methylolivomycin D
Rufocromomycin
Butyl-2-naphthylether
6-Phenylhexan-2-on
o-Octylphenol
1'-Hydroxy-2'-acetonaphthon
- chromomycina(sub3)
- nosyl)-7-methyl-
- nsc-58514
- olivomycind,3b-o-(4-o-acetyl-2,6-dideoxy-3-c-methyl-alpha-l-arabinohexopyra
- TOYOMYCIN
- 3BETA-O-(4-O-ACETYL-2.6-DIDEOXY-3-C-METHYL-ALPHA-L-ARABINO HEXOPYRANOSYL)-7-METHYLOLIVOMYCIN D
- 3B-O-(4-O-ACETYL-2,6-DIDEOXY-3-C-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSYL)-7-METHYLOLIVOMYCIN D
- 3B-O-(4-O-ACETYL-2,6-DIDEXY-3-C-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSYL)-7-METHYLOLIVOMYCIN
- ABURAMYCIN BETA
- CHROMOMYCIN A3
- CHROMOMYCIN A3 STREPTOMYCES GRISEUS
- 3D-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-7-methylolivomycin D
- CHROMOMYCIN A(3), FOR FLUORESCENCE
- CHROMOMYCIN A3 FROM STREPTOMYCESGRISEUS APPROX. 96
- Chromomycin
- D-threo-2-Pentulose, 1-C-(2S,3S)-7-4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-.alpha.-D-lyxo-hexopyranosyl)-.beta.-D-lyxo-hexopyranosyloxy-3-O-4-O-acetyl-2,6-dideoxy-3-C-methyl-.alpha.-L-arabino-hexopyranosyl-(1?3)-O-2,6-dideoxy-.beta.-D-arabino-h
- chromomycin a3from streptomyces griseus
- 3'''-O-(4-O-Acetyl-3-C-methyl-2,6-dideoxy-α-L-arabino-hexopyranosyl)-7-methylolivomycin D
- Chromoycin A3
- Olivomycin D
- AburaMycin, ToyoMycin, NSC 58514, B 599-III, SR1768E
- aburamycinb
- antibiotic69895a
- antibioticb599
- Chromomycin A - CAS 7059-24-7 - Calbiochem
- [(2R,3S,4R,6S)-6-[[(6S,7S)-6-[(2S,4R,5R,6R)-4-[(2S,4R,5R,6R)-4-[(2S,4S,5S,6S)-5-acetyloxy-4-hydroxy-4,6-dimethyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-7-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-4,10-dihydroxy-3-methyl-5-oxo-7,8-dihydro-6H-anthracen-2-yl]oxy]-4-[(2R,4R,5R,6R)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy-2-methyloxan-3-yl] acetate
- D-threo-2-Pentulose, 1-C-[(2S,3S)-7-[[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-D-lyxo-hexopyranosyl)-β-D-lyxo-hexopyranosyl]oxy]-3-[[O-4-O-acetyl-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy...
- CHROMOMYCIN A3 USP/EP/BP
- Chromomycin A3, fluorescent DNA stain
- Chromomycin A3 from Streptomyces griseus
- Chromomycin A3
- 7059-24-7
- C57H82O26
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