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WIN 55,212-2 MESYLATE

WIN 55,212-2 MESYLATE Struktur
131543-23-2
CAS-Nr.
131543-23-2
Englisch Name:
WIN 55,212-2 MESYLATE
Synonyma:
WIN55;CS-754;WIN 55,212-2;212-2Mesylate;WIN552122;WIN-552122;WIN 55,212-2 MESYLATE;R(+)-WIN 55,212-2 MESYLATE;WIN 55212-2 methanesulfonate;(R)-(+)-WIN 55,212-2 mesylate salt;WIN552122;WIN-552122;(R)-(+)-WIN 55212
CBNumber:
CB8335502
Summenformel:
C28H30N2O6S
Molgewicht:
522.62
MOL-Datei:
131543-23-2.mol

WIN 55,212-2 MESYLATE Eigenschaften

storage temp. 
Store at +4°C
L?slichkeit
0.1 M HCl: 0.25 mg/mL
Aggregatzustand
solid
Farbe
white to off-white
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey
FSGCSTPOPBJYSX-OZYVVJTJNA-N
SMILES
S(O)(=O)(=O)C.C(N1CCOCC1)[C@@H]1COC2=CC=CC3C(C(C4=CC=CC5=CC=CC=C45)=O)=C(C)N1C=32 |&1:12,r|

Sicherheit

WGK Germany  3

WIN 55,212-2 MESYLATE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

(+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve. This effect is fully counteracted by rimonabant at a concentration of 10 nM, by decreasing Ca2+ concentrations below 0.2 mM, or by the IP3 receptor antagonist xestospongin C at a concentration of 1 μM. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC50 value of 26 μM.

Verwenden

(R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/? mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.

Allgemeine Beschreibung

WIN 55,212-2 is a member of the aminoalkylindole class of compounds.

Biologische Aktivit?t

Nanomolar affinity cannabinoid receptor agonist (K i values are 62.3 and 3.3 nM at the human cloned CB 1 and CB 2 receptors respectively). Also available as part of the Cannabinoid Receptor Agonist Tocriset™ .

WIN 55,212-2 MESYLATE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


WIN 55,212-2 MESYLATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 153)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Kangcang new material Technology Co., LTD
+8615713292910
Nancy@kangcang.com.cn China 341 58
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
bruce@xrdchem.cn CHINA 566 55
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 965 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
TopScience Biochemical
00852-68527855
info@itopbiochem.com China Hong Kong 902 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29810 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
Shanghai UCHEM Inc.
+862156762820 +86-13564624040
sales@myuchem.com China 7629 58

131543-23-2()Verwandte Suche:


  • R(+)-WIN 55,212-2 ,MESYLATE HIGH AFFINIT Y CANNABI
  • (R)-(+)-(2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1.2.3-de]-1,4-benzoxazin-6-yl)-1-naphthalenylmethanonemesy
  • 212-2Mesylate
  • WIN55
  • (R)-(+)-[2,3-Dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt
  • (R)-(+)-WIN 55,212-2 mesylate salt
  • WIN 552122 mesylate, (R)-(+)-[2,3-Dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt
  • (R)-(5-Methyl-3-(MorpholinoMethyl)-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indol-6-yl)(naphthalen-1-yl)Methanone
  • (R)-(5-Methyl-3-(MorpholinoMethyl)-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indol-6-yl)(naphthalen-1-yl)Methanone Methanesulfonate
  • (R)-(5-Methyl-3-(morpholinomethyl)-2,3-dihydro-[1,4]oxazino-[2,3,4-hi]indol-6-yl)(naphthalen-1-yl
  • WIN 55212-2 methanesulfonate
  • (R)-(5-Methyl-3-(morpholinomethyl)-2,3-dihydro-[1,4]oxazino-[2,3,4-hi]indol-6-yl)(naphthalen-1
  • (R)-(+)-[2,3-DIHYDRO-5-METHYL-3-(4-MORPHOLINYLMETHYL)PYRROLO[1,2,3-DE]-1,4-BENZOXAZIN-6-YL]-1-NAPHTHALENYLMETHANONE MESYLATE
  • R(+)-[2,3-DIHYDRO-5-METHYL-3-[(MORPHOLINYL)METHYL]PYRROLO[1,2,3-DE]-1,4-BENZOXAZINYL]-(1-NAPHTHALENYL)METHANONE MESYLATE
  • R(+)-WIN 55,212-2 MESYLATE
  • WIN 55,212-2 MESYLATE
  • WIN 55,212-2
  • (+)-WIN 55,212-2 mesylate - CAS 131543-23-2 - Calbiochem
  • CS-754
  • WIN552122;WIN-552122
  • WIN552122;WIN-552122;(R)-(+)-WIN 55212
  • [(3R)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone Monomethanesulfonate
  • (R)-(+)-WIN 55,212-2 mesylate salt >=98% (HPLC)
  • (R)-(+)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo1,2,3-de-1,4-benzoxazin-6-yl-1-naphthalenylmethan one mesylate
  • 131543-23-2
  • C28H30N2O6S
  • Cannabinoid receptor
  • Cannabinoid
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