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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Struktur
5184-64-5
CAS-Nr.
5184-64-5
Englisch Name:
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
Synonyma:
ESI-05;NSC 116966;ESI-05 (ESI05);ESI-05 (NSC 116966);ESI-05 >=98% (HPLC);ESI-05, 10 mM in DMSO;MESITYL P-TOLYL SULFONE;1,3,5-trimethyl-2-tosylbenzene;1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene;Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
CBNumber:
CB83290819
Summenformel:
C16H18O2S
Molgewicht:
274.38
MOL-Datei:
5184-64-5.mol

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Eigenschaften

Schmelzpunkt:
119-120 °C
Siedepunkt:
426.7±45.0 °C(Predicted)
Dichte
1.129±0.06 g/cm3(Predicted)
storage temp. 
room temp
L?slichkeit
DMSO: soluble
Aggregatzustand
powder
Farbe
white to beige

Sicherheit

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

ESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury.

Biochem/physiol Actions

ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 μM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants.

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 43)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569266 15319487004
 1015@dideu.com China 3954 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32265 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Aladdin Scientific
tp@aladdinsci.com United States 57505 58
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51456 80
BOC Sciences 16314854226
 info@bocsci.com United States 9923 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9803 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903
 3008007409@qq.com China 71829 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
 klq@cw-bio.com China 6389 55
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 17801761073
 3193328036@qq.com China 29763 68
  • Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
  • 1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene
  • MESITYL P-TOLYL SULFONE
  • ESI-05
  • ESI-05 (ESI05)
  • 1,3,5-trimethyl-2-tosylbenzene
  • NSC 116966
  • ESI-05 >=98% (HPLC)
  • ESI-05 (NSC 116966)
  • Diacylglycerol acyltransferase,diabetes,Inhibitor,inhibit,Intracranial hemorrhage (ICH),Acyltransferase,cAMP,acyl-CoA:cholesterol acyltransferase,NSC116966,insulin secretion,mono- acylglycerol acyltransferase,exchange proteins directly activated by cAMP 2 (EPAC2),neurological disorders,NSC-116966,GEF,Diglyceride acyltransferase,ESI 05,ESI-05,ESI05
  • ESI-05, 10 mM in DMSO
  • 5184-64-5
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