NCT-503
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- CAS-Nr.
- 1916571-90-8
- Englisch Name:
- NCT-503
- Synonyma:
- NCT-503;CS-2612;NCT 503;NCT503;NCT-503 >=98% (HPLC);NCT-503; NCT 503; NCT503.;inhibit,NCT-503,NCT503,Inhibitor;N-(4,6-Dimethylpyridin-2-yl)-4-(4-(trifluoromethyl)benzyl)piperazine-1-carbothioamide;1-Piperazinecarbothioamide, N-(4,6-dimethyl-2-pyridinyl)-4-[[4-(trifluoromethyl)phenyl]methyl]-;9-(6-aminopyridin-3-yl)-1-(4-fluoro-3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one
- CBNumber:
- CB83159381
- Summenformel:
- C20H23F3N4S
- Molgewicht:
- 408.48
- MOL-Datei:
- 1916571-90-8.mol
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NCT-503 Eigenschaften
- Siedepunkt:
- 474.3±55.0 °C(Predicted)
- Dichte
- 1.306±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- ≥40.9 mg/mL in DMSO; insoluble in H2O; ≥20.33 mg/mL in EtOH
- Aggregatzustand
- powder
- pka
- 12.99±0.20(Predicted)
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
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NCT-503 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC
50 value of 2.5 μM. It has been shown to reduce the production of glucose-derived serine in cells and to suppress the growth of PHGDH-dependent MDA-MB-468 cancer cells both
in vitro and in mice bearing orthotopic xenograft tumors.
Verwenden
NCT-503 is a novel inhibitor of human Phosphoglycerate Dehydrogenase (PHGDH).
Biochem/physiol Actions
NCT-503 is an inhibitor of phosphoglycerate dehydrogenase (PHGDH), which catalyzes the first, rate-limiting step of glucose-derived serine synthesis. NCT-503 reduced glucose-derived serine production and suppressed the growth of both PHGDH-dependent cancer cells in culture and in xenograft tumors, and caused G1/S cell cycle arrest in MDA-MB-468 cells. NCT-503 reduced the incorporation of one-carbon units from glucose-derived and exogenous serine into nucleotides, which may contribute to its anticancer activity. NCT-503 had an IC50 value of 2.5 μM for PHGDH and was inactive against a panel of other dehydrogenases and minimal cross-reactivity in a panel of 168 G-protein-coupled receptors (GPCRs). NCT-503 was found to be noncompetitive with respect to both 3-PG and NAD+, and exhibit good stability (>98% after 48 hrs in assay buffer) and aqueous solubility.
NCT-503 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
NCT-503 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 79)Lieferanten
- NCT-503
- 9-(6-aminopyridin-3-yl)-1-(4-fluoro-3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one
- NCT 503;NCT503
- CS-2612
- NCT-503; NCT 503; NCT503.
- 1-Piperazinecarbothioamide, N-(4,6-dimethyl-2-pyridinyl)-4-[[4-(trifluoromethyl)phenyl]methyl]-
- NCT-503 >=98% (HPLC)
- inhibit,NCT-503,NCT503,Inhibitor
- N-(4,6-Dimethylpyridin-2-yl)-4-(4-(trifluoromethyl)benzyl)piperazine-1-carbothioamide
- 1916571-90-8
- C20H23F3N4S
