MMP-12 Inhibitor Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC₅₀ = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC₅₀ = 160, 320 and 22.3 nM, respectively) or human MMP-3/13/14 (IC₅₀ = 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC₅₀ >5 μM), TACE (IC₅₀ >25 μM), and MMP-1/7 (IC₅₀ >6 μM). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in mice in vivo by more than 50% (5 mg/kg, p.o., b.i.d.).

MMP-12 Inhibitor Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MMP-12 Inhibitor Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Alabiotech Inc.	001-619-354-5251	sales@alabiotech-e.com	United States	972	60
Alpha Biopharmaceuticals Co., Ltd	0411-39042497	sales@alphabiopharm.com	China	1951	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	12000	58

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• MMP-12 Inhibitor
• MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem
• D-Valine, N-[[8-[(methoxycarbonyl)amino]-3-dibenzofuranyl]sulfonyl]-
• 1258003-93-8